Normal-appearing White and Grey Matter Damage in Multiple Sclerosis

  • Giancarlo Comi
  • Massimo Filippi
  • Marco Rovaris

Part of the Topics in Neuroscience book series (TOPNEURO)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Normal-Appearing White Matter

  3. Normal-Appearing Grey Matter

    1. Front Matter
      Pages 99-99
    2. B. P. Brink, S. J. Mork, P. Van Der Valk, L. Bo
      Pages 101-109
    3. O. Gonen, M. Inglese, R. I. Grossman
      Pages 129-143
    4. M. Filippi, M. A. Rocca
      Pages 145-155
  4. Back Matter
    Pages 157-159

About this book


In the last few years, increasing effort has been devoted to better define the characteristics of tissue damage occurring outside MRI-visible lesions in patients with multiple sclerosis (MS) and, as a consequence, to improve our understanding of the disease pathobiology and of the mechanisms leading to the accumulation of irreversible disability. This book provides an updated review of the results obtained by leading research groups in this field. The potential clinical applications of what has been shown so far, as well as the areas for future research in the study of normal-appearing white and gray matter damage in MS are extensively discussed, making this book a valuable tool for clinical neurologists who are involved in the daily-life care of MS patients and for neuroscientists involved in MS research.


Function MRI brain clinical application diffusion-tensor MRI functional magnetic resonance imaging (fMRI) magnetic resonance magnetic resonance imaging magnetic resonance imaging (MRI) magnetization transfer MRI multiple sclerosis

Editors and affiliations

  • Giancarlo Comi
    • 1
  • Massimo Filippi
    • 2
  • Marco Rovaris
    • 2
  1. 1.Department of Neurology Scientific InstituteUniversity Ospedale San RaffaeleMilanItaly
  2. 2.Neuroimaging Research Unit Department of NeuroscienceScientific Institute and University Ospedale San RaffaeleMilanItaly

Bibliographic information