Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach

  • Francesco Saverio De Ponte

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Robert E. Marx
    Pages 1-11
  3. Angelina De Sarro, Letteria Minutoli
    Pages 13-22
  4. Giuseppe Altavilla, Grazia Marabello, Chiara Tomasello, Vincenzo Pitini
    Pages 23-34
  5. Caterina Musolino, Alessandro Allegra
    Pages 35-48
  6. Angelina De Sarro, Letteria Minutoli
    Pages 49-57
  7. Giuseppina Cutroneo
    Pages 59-71
  8. Santino Ferrara, Laura Vuolo, Annamaria Colao, Luigi Califano
    Pages 73-84
  9. Silvio Mazziotti, Achille Mileto, Michele Gaeta, Giorgio Ascenti, Ignazio Salamone, Carmela Visalli et al.
    Pages 85-95
  10. Stefania Leuci, Marco Friscia, Michele Davide Mignogna
    Pages 97-103
  11. Giacomo Oteri
    Pages 105-120
  12. Alessandro Agrillo
    Pages 121-125
  13. Claudio Marchetti, Gian Andrea Pelliccioni, Filippo Moretti, Francesco Saverio De Ponte, Giuseppe Lombardo, Carla Nava
    Pages 141-156
  14. Luciano Catalfamo, Carla Nava, Giuseppe Lombardo, Francesco Saverio De Ponte
    Pages 157-166
  15. Salvatore L. Ruggiero
    Pages 167-178
  16. Back Matter
    Pages 179-181

About this book


Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing ONJ are much higher for cancer patients on intravenous bisphosphonate therapy (used to reduce bone pain), the occurrence of ONJ also in patients treated with oral BF for osteoporosis has been also highlighted, though rarely. On the basis of the large use of BF, of their pharmacokinetics, of the systemic and local risk factors, physicians prescribing them and dental surgeons should be well informed on the various aspects of the problem. Aim of this volume is to offer an update on the current status of prevention, and on the current conservative and surgical treatments. The multidisciplinary approach will be very much appreciated by GP’s, the different specialists using bisphosphonates and by dental surgeons.


bisphosphonates osteonecrosis pharmacology surgery tumor

Editors and affiliations

  • Francesco Saverio De Ponte
    • 1
  1. 1., Dental DepartmentUniversity of MessinaMessinaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Italia 2012
  • Publisher Name Springer, Milano
  • eBook Packages Medicine
  • Print ISBN 978-88-470-2082-5
  • Online ISBN 978-88-470-2083-2
  • Buy this book on publisher's site