HCV Infection and Cryoglobulinemia

  • Franco Dammacco

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Hepatitis C Virus Infection and the Role of the Immune System

    1. Front Matter
      Pages 9-9
    2. Franco Dammacco, Domenico Sansonno
      Pages 1-8
    3. Edgar D. Charles, Lynn B. Dustin, Charles M. Rice
      Pages 11-19
    4. Lynn B. Dustin
      Pages 21-36
    5. Vito Racanelli, Claudia Brunetti
      Pages 37-41
    6. Corrado Betterle, Fabio Presotto
      Pages 43-51
  3. Cellular Compartments of HCV Infection (and Replication)

    1. Front Matter
      Pages 53-53
    2. Franco Dammacco, Vito Racanelli
      Pages 63-68
    3. Tram N. Q. Pham, Tomasz I. Michalak
      Pages 69-75
  4. Cryoglobulinemia and the Complement System

    1. Front Matter
      Pages 77-77
    2. Jürg A. Schifferli, Marten Trendelenburg
      Pages 79-83
    3. Marten Trendelenburg
      Pages 85-89
    4. Domenico Sansonno, Loredana Sansonno, Franco Dammacco
      Pages 91-96
  5. Structural and Genetic Features, Cytokines and Chemokines in Cryoglobulinemia

    1. Front Matter
      Pages 97-97
    2. Sabino Russi, Silvia Sansonno, Gianfranco Lauletta, Domenico E. Sansonno, Franco Dammacco
      Pages 127-135
    3. Alessandro Antonelli, Clodoveo Ferri, Silvia Martina Ferrari, Michele Colaci, Ilaria Ruffilli, Caterina Mancusi et al.
      Pages 137-141
  6. Clinical Manifestations of Cryoglobulinemia

    1. Front Matter
      Pages 143-143
    2. Charles E. Alpers, Tomasz A. Wietecha, Kelly L. Hudkins
      Pages 145-153
    3. Clodoveo Ferri, Alessandro Antonelli, Marco Sebastiani, Michele Colaci, Anna Linda Zignego
      Pages 155-162
    4. Salvatore De Vita, Luca Quartuccio
      Pages 163-167
    5. Giuseppe Monti, Francesco Saccardo, Laura Castelnovo
      Pages 169-173
    6. Christos P. Argyropoulos, Sheldon Bastacky, John Prentiss Johnson
      Pages 175-183
    7. Gianfranco Ferraccioli, Francesca Faustini, Elisa Gremese
      Pages 185-190
    8. Alessandro Antonelli, Clodoveo Ferri, Silvia Martina Ferrari, Michele Colaci, Alda Corrado, Andrea Di Domenicantonio et al.
      Pages 191-194
    9. Konstantinos Linos, Bernard Cribier, J. Andrew Carlson
      Pages 195-207
    10. Salvatore Monaco, Sara Mariotto, Sergio Ferrari
      Pages 209-217
    11. Damien Sene, Patrice P. Cacoub
      Pages 219-226
    12. Massimo Galli, Salvatore Sollima
      Pages 227-231
    13. Massimo Galli, Salvatore Sollima, Giuseppe Monti
      Pages 239-243
    14. Lionel Rostaing, Hugo Weclawiak, Nassim Kamar
      Pages 245-250
  7. HCV Infection, Cryoglobulinemia and Non-Hodgkin’s Lymphomas

    1. Front Matter
      Pages 251-251
    2. Cristina Mecucci, Gianluca Barba, Caterina Matteucci
      Pages 253-257
    3. Valli De Re, Maria Paola Simula
      Pages 259-265
    4. Pietro Enrico Pioltelli, Giuseppe Monti, Maurizio Pietrogrande, Massimo Galli
      Pages 273-275
  8. Therapy of Cryoglobulinemia

    1. Front Matter
      Pages 285-285
    2. José Luis Calleja Panero, Juan de la Revilla Negro, Fernando Pons Renedo
      Pages 287-295
    3. Francesco Zaja, Stefano Volpetti, Stefano De Luca, Renato Fanin
      Pages 297-305
    4. Peter Lamprecht, Paul Klenerman
      Pages 307-313
    5. Franco Dammacco, Domenico Sansonno
      Pages 315-323
    6. Franco Dammacco, Cinzia Conteduca, Domenico Sansonno
      Pages 325-334

About this book


In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These “cryoglobulins” were responsible for the corresponding clinical condition “cryoglobulinemia.” Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepatitis C virus infection.

The book is unique in its detailed presentation and fundamental approach. Highly qualified authors have contributed critical articles reviewing significant developments in our understanding of and therapeutic approach to HCV infection and cryoglobulinemia. The text is accompanied by striking color images and illustrations and highly informative tables.

This comprehensive review of a systemic disease with a complex etiology is a valuable source of up-to-date, expert information not only for basic scientists and specialists in several disciplines but also for general practitioners as well as graduate and post-graduate students in clinical and medical research.


Autoimmunity Cryoglobulinemia HCV Immune Complex Diseases Malignant Lymphoma

Editors and affiliations

  • Franco Dammacco
    • 1
  1. 1., Department of Internal Medicine and ClinUniversity of BariBariItaly

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Italia 2012
  • Publisher Name Springer, Milano
  • eBook Packages Medicine
  • Print ISBN 978-88-470-1704-7
  • Online ISBN 978-88-470-1705-4
  • Buy this book on publisher's site