Cachexia and Wasting: A Modern Approach

  • Giovanni Mantovani
  • Stefan D. Anker
  • Akio Inui
  • John E. Morley
  • Filippo Rossi Fanelli
  • Daniele Scevola
  • Michael W. Schuster
  • Shing-Shing Yeh

Table of contents

  1. Front Matter
    Pages I-XXII
  2. Anatomy, Historical Perspective and Epidemiology

    1. Front Matter
      Pages 1-1
    2. Giovanni Mantovani, Clelia Madeddu
      Pages 39-43
  3. Biochemistry, Physiology and ‘Clinics’ of Adipose Tissue

    1. Front Matter
      Pages 45-45
    2. Gianni Tomassi, Nicolò Merendino
      Pages 47-52
    3. Gianni Tomassi, Nicolò Merendino
      Pages 53-56
  4. Assessment of Nutritional Status

    1. Front Matter
      Pages 57-57
    2. Emine M. Inelmen, Giuseppe Sergi
      Pages 59-72
    3. Paolo Tessari, Renato Millioni
      Pages 81-92
    4. Daniele Scevola, Angela Di Matteo, Omar Giglio, Silvia Scevola
      Pages 93-110
    5. Clelia Madeddu, Giovanni Mantovani
      Pages 111-124
    6. Max Dahele, Kenneth C. H. Fearon
      Pages 125-135
  5. The Different Features of Wasting in Humans

    1. Front Matter
      Pages 137-137
    2. Alessandro Laviano, Michael M. Meguid, Filippo Rossi Fanelli
      Pages 139-148
    3. Daniele Scevola, Angela Di Matteo, Omar Giglio, Filippo Uberti
      Pages 149-160
    4. Giovanni Mantovani, Clelia Madeddu
      Pages 161-162
    5. Giuliano Enzi, Luca Busetto, Giuseppe Sergi, Sabrina Pigozzo
      Pages 163-171
  6. Pathophysiology of Wasting/Cachexia

    1. Front Matter
      Pages 173-173
    2. Giuseppe Sergi, Pietro Bonometto, Alessandra Coin, Giuliano Enzi
      Pages 175-183
    3. Michael J. Tisdale
      Pages 185-190
    4. Enzo Manzato, Giovanna Romanato
      Pages 191-194
    5. Antonio Macciò, Clelia Madeddu, Giovanni Mantovani
      Pages 195-203
    6. Giovanni Mantovani
      Pages 205-207
    7. Wolfgang Langhans
      Pages 209-217
    8. Cyril Y. Bowers, Jaw-Kang Chang, Shaoxing Wu, Klaus D. Linse, David L. Hurley, Johannes D. Veldhuis
      Pages 219-234
    9. Fabio Broglio, Cristina Gottero, Flavia Prodam, Elisa Me, Silvia Destefanis, Fabrizio Riganti et al.
      Pages 235-245
    10. Carlos R. Plata-Salaman
      Pages 259-268
    11. Flavia Prodam, Elisa Me, Fabrizio Riganti, Maria Angela Seardo, Barbara Lucatello, Mario Maccario et al.
      Pages 269-280
  7. Medical Causes of Wasting/Cachexia

    1. Front Matter
      Pages 281-281
    2. Takeshi Ohara
      Pages 283-289
    3. Laura Gianotti, Andrea Picu, Fabio Lanfranco, Francesco Tassone, Matteo Baldi, Roberta Giordano et al.
      Pages 291-299
    4. Adelio Lucca, Enrico Smeraldi
      Pages 301-304
    5. Hiroyuki Okano
      Pages 327-338
    6. Sabine Strassburg, Stefan D. Anker
      Pages 349-361
  8. Cachexia and Ageing

    1. Front Matter
      Pages 363-363
    2. Shing-Shing Yeh, Michael W. Schuster
      Pages 365-368
    3. Alessandra Coin, Giuseppe Sergi, Emine M. Inelmen, Giuliano Enzi
      Pages 369-375
    4. Dario Cova, Vito Lorusso, Nicola Silvestris
      Pages 377-382
    5. Osama QuBaiah, John E. Morley
      Pages 383-395
    6. David R. Thomas
      Pages 397-404
  9. Cachexia and HIV Infection/AIDS

    1. Front Matter
      Pages 405-405
    2. Daniele Scevola, Angela Di Matteo, Omar Giglio, Filippo Uberti
      Pages 407-428
    3. Daniele Scevola, Omar Giglio, Silvia Scevola
      Pages 429-456

About this book


Cachexia may well represent the flip side of the tremendous achievements of modern medicine.

Many diseases rapidly leading patients to death just a few years ago, are now better controlled by new therapies, and even if we cannot cure and eradicate them, their natural history has significantly increased by months and years. Although these new therapeutic strategies represent a remarkable advantage over the standards of care, it is impossible to ignore that many more patients are now facing the nutritional consequences of prolonged immunological and metabolic challenges deriving from ongoing diseases and aggressive therapies.

Aim of the volume, written by world-renowned scientists, is to provide the best available evidence on the pathogenesis, clinical features and therapeutic approach of cachexia, and to facilitate the understanding of the complex yet unequivocal clinical role of this syndrome, that truly represents a disease, or, better still, a disease within other different diseases.


Diabetes HIV HIV infection aging assessment cancer depression geriatric oncology geriatrics infectious disease infectious diseases oncology pathophysiology physiology tissue

Editors and affiliations

  • Giovanni Mantovani
    • 1
  • Stefan D. Anker
    • 2
    • 3
  • Akio Inui
    • 4
  • John E. Morley
    • 5
  • Filippo Rossi Fanelli
    • 6
  • Daniele Scevola
    • 7
  • Michael W. Schuster
    • 8
  • Shing-Shing Yeh
    • 9
  1. 1.Department of Medical OncologyUniversity of CagliariCagliariItaly
  2. 2.Department of Clinical CardiologyImperial College, NHLILondonUK
  3. 3.Department of Cardiology CharitéApplied Cachexia ResearchCampus Virchow-Klinikum, BerlinGermany
  4. 4.Department of Behavioral MedicineKagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan
  5. 5.GRECC, VA Medical Center and Division of Geriatric MedicineSaint Louis UniversitySt. LouisUSA
  6. 6.Department of Clinical MedicineUniversity of RomeLa Sapienza, RomeItaly
  7. 7.Department of Infectious Diseases, IRCCS S.Matteo PolyclinicUniversity of PaviaPaviaItaly
  8. 8.Bone Marrow and Blood Stem Cell Transplantation ProgramCenter for Lymphoma and Myeloma, New York Presbyterian Hospital/Weill Medical CenterNew YorkUSA
  9. 9.Department of Medicine-GeriatricsUniversity of New York at Stony Brook VAMCNorthportUSA

Bibliographic information