Neurodegeneration in Multiple Sclerosis

  • Massimo Filippi
  • Marco Rovaris
  • Giancarlo Comi

Part of the Topics in Neuroscience book series (TOPNEURO)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Background

    1. Front Matter
      Pages 1-1
    2. E. Capello, A. Uccelli, M. Pizzorno, G.L. Mancardi
      Pages 3-9
    3. L. Leocani, G. Comi
      Pages 11-20
  3. MRI Techniques to Assess Neurodegeneration

    1. Front Matter
      Pages 21-21
    2. W. Rashid, D.T. Chard, D.H. Miller
      Pages 23-35
    3. M. Neema, V.S.R. Dandamudi, A. Arora, J. Stankiewicz, R. Bakshi
      Pages 37-45
    4. M. Inglese, Y. Ge, R.I. Grossman
      Pages 47-53
    5. Y. Ge, M. Law, M. Inglese, R.I. Grossman
      Pages 55-64
    6. M. Rovaris, E. Perego, M. Filippi
      Pages 65-74
    7. N. De Stefano
      Pages 75-83
    8. M. A. Rocca, M. Filippi
      Pages 85-104
  4. Evaluation of MRI Outcomes

    1. Front Matter
      Pages 105-105
    2. M. P. Sormani, M. Filippi
      Pages 107-112
    3. I. Aban, G. Cutter
      Pages 113-125
    4. K. Mouridsen, L. Østergaard
      Pages 127-149
  5. Lessons from Other Neurodegenerative Diseases

    1. Front Matter
      Pages 151-151
    2. G. B. Frisoni
      Pages 153-161
    3. M. Mascalchi
      Pages 163-181
    4. S. Gnanapavan, G. Giovannoni
      Pages 183-207
  6. Designing MS Trials for Neurodegeneration

    1. Front Matter
      Pages 209-209
    2. G. Comi
      Pages 211-220
    3. P. Soelbergs Sørensen
      Pages 221-232
  7. Back Matter
    Pages 233-236

About this book


In multiple sclerosis (MS), conventional magnetic resonance imaging (cMRI) has proved to be a valuable tool to increase diagnostic reliability and to monitor the efficacy of experimental treatment. However, cMRI has limited specificity and accuracy as to the most disabling aspects of the MS pathology, known to occur in and outside macroscopic lesions. Modern quantitative MR techniques have the potential to overcome the limitations of cMRI, and their application is dramatically changing our understanding of how MS causes irreversible disability. Written by world-renowned scientists, the volume is indispensable for anybody working in this field.


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Editors and affiliations

  • Massimo Filippi
    • 1
  • Marco Rovaris
    • 1
  • Giancarlo Comi
    • 2
  1. 1.Neuroimaging Research Unit Department of NeurologyScientific Institute and University Ospedale San RaffaeleMilanItaly
  2. 2.Department of NeurologyScientific Institute and University Ospedale San RaffaeleMilanItaly

Bibliographic information