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Biomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges

  • Sanjeeva Srivastava

Table of contents

  1. Front Matter
    Pages i-xi
  2. Shabarni Gupta, Vimala Ashok Mani, Arunanshu Talukdar, Kunal Sehgal, C. S. Pramesh, Aliasgar Moiyadi et al.
    Pages 1-7
  3. Shabarni Gupta, Sandipan Ray, Arunanshu Talukdar, Kunal Sehgal, Aliasgar Moiyadi, Sanjeeva Srivastava
    Pages 9-17
  4. Saicharan Ghantasala, Shabarni Gupta, Vimala Ashok Mani, Vineeta Rai, Tumpa Raj Das, Panga Jaipal Reddy et al.
    Pages 19-39
  5. Panga Jaipal Reddy, Kishore Gollapalli, Saicharan Ghantasala, Tumpa Das, Sandip Kumar Patel, Venkatesh Chanukuppa et al.
    Pages 41-63
  6. Sandipan Ray, Sanjeeva Srivastava, Shyam Diwakar, Bipin Nair, Vural Özdemir
    Pages 73-81
  7. Anurag S. Rathore, Sumit K. Singh, Neh Nupur, Gunjan Narula
    Pages 83-97
  8. Tumpa Raj Das, Apoorva Venkatesh, Apurva Atak, Shabarni Gupta, Prasad B. Phapale
    Pages 99-115
  9. Back Matter
    Pages 117-118

About this book

Introduction

This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker “life cycle” with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being used for biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With theneed for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of “social innovation” to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and prominence recently due to their immense potential in clinical and pharmaceutical innovation literatures. The broader goal post-biomarker discovery is to translate their use in clinics. However, the road from bench-to-bed side is arduous and complex that is subject to oversight from various national and international regulatory bodies. Chapter 8 underscores these regulatory science considerations and provides a concise overview on intellectual property rights in biomarker discovery. Thus, this book contributed by eminent biomarker scientists, clinicians, translational researchers and social scientists holistically covers the various facets of the biomarker discovery journey from “cell to society” in developing world. The lessons learned and highlighted here are of interest to the life sciences community in a global and interdependent world.

Keywords

Biomarker Discovery Drug discovery Patents and intellectual property rights Proteomics Research funding Research in Developing World

Editors and affiliations

  • Sanjeeva Srivastava
    • 1
  1. 1.Department of Biosciences and BioengineeringIIT BombayMumbaiIndia

Bibliographic information