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Proteostasis and Chaperone Surveillance

  • Laishram Rajendrakumar Singh
  • Tanveer Ali Dar
  • Parvaiz Ahmad

Table of contents

  1. Front Matter
    Pages i-xii
  2. Maintaining Proteostasis

    1. Front Matter
      Pages 1-1
    2. Gurumayum Suraj Sharma, Marina Warepam, Laishram Rajendrakumar Singh, Tanveer Ali Dar
      Pages 39-59
  3. Proteopathy: Failure of Proteostasis

    1. Front Matter
      Pages 61-61
    2. Atiyatul Qadeer, Nida Zaidi, Rizwan H. Khan
      Pages 63-87
    3. Mahmood Rasool, Arif Malik, Abdul Manan, Misbah Sultana, Mahmood Husain Qazi, Peter Natesan Pushparaj
      Pages 89-103
    4. Iram Ashaq, Amin Shajrul, Masood Akbar, Fouzia Rashid
      Pages 105-118
    5. Iftikhar Aslam Tayubi, Ahmad Firoz, Adeel Malik
      Pages 119-135
  4. Chaperone Surveillance of Proteopathy

    1. Front Matter
      Pages 137-137
    2. Rimpy K. Chowhan, Tanveer Ali Dar, Laishram R. Singh
      Pages 139-169
    3. Shruti Mittal, Mohd Younus Bhat, Tarun Kumar, Parvaiz Ahmad, Safikur Rahman, Hamidur Rahaman
      Pages 171-180

About this book

Introduction

Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances, and the essential role of molecular and chemical chaperones.

Keywords

Chaperones Molecular biology Mutation Protein aggregation Protein folding Protein misfolding disorders

Editors and affiliations

  • Laishram Rajendrakumar Singh
    • 1
  • Tanveer Ali Dar
    • 2
  • Parvaiz Ahmad
    • 3
  1. 1.Dr. B. R. Ambedkar Center for Biomedical ResearchUniversity of DelhiNew DelhiIndia
  2. 2.Clinical BiochemistryUniversity of KashmirSrinagarIndia
  3. 3.Department of BotanyUniversity of KashmirSrinagarIndia

Bibliographic information