© 2010

Moyamoya Disease Update

  • Byung-Kyu Cho
  • Teiji Tominaga
  • Providing the latest knowledge of Moyamoya Disease


Table of contents

  1. Front Matter
    Pages i-xx
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Teiji Tominaga
      Pages 3-11
    3. Kent Doi, Ken-ichiro Kikuta
      Pages 12-22
    4. Chang-Wan Oh, Gyojun Hwang
      Pages 23-25
  3. Epidemiology

    1. Front Matter
      Pages 27-27
    2. Koichi Oki, Haruhiko Hoshino, Norihiro Suzuki
      Pages 29-34
    3. Joong-Uhn Choi
      Pages 35-37
  4. Genetics

    1. Front Matter
      Pages 39-39
    2. Shigeo Kure
      Pages 41-45
    3. Shigeo Kure
      Pages 46-50
    4. Hyun-Seung Kang, Kyu-Chang Wang
      Pages 51-53
    5. Myoung Hee Park, Seok Ho Hong, Kyu-Chang Wang
      Pages 54-59
  5. Pathophysiology I: Protein, Cell, and Immunology

    1. Front Matter
      Pages 61-61
    2. Seung-Ki Kim, Kyu-Chang Wang, Byung-Kyu Cho
      Pages 63-68
    3. Jin Hyun Kim, Seung-Ki Kim, Kyu-Chang Wang
      Pages 73-81
    4. Ji Hoon Phi, Seung-Ki Kim, Kyu-Chang Wang, Byung-Kyu Cho
      Pages 82-86
  6. Pathophysiology II: Hemodynamics, Biomechanical Aspect

    1. Front Matter
      Pages 87-87
    2. Jeong Chul Kim, Eun Bo Shim
      Pages 89-98

About this book


Moyamoya disease (MMD) was first reported as a new entity among vascular disorders in 1957. Named for the abnormal vascular networks found around the occluded distal internal carotid artery, it is the most common pediatric cerebrovascular disease in East Asia. In recent years large amounts of data on MMD have been collected and important investigations have been carried out in Japan and Korea, even as the pathophysiology of the disease remains to be discovered. This monograph covers a diversity of topics and presents a systematic compilation of the data and current status of MMD in clinical practice and basic research. With contributions by more than 70 authors, the book includes sections on genetics, computational analysis of hemodynamic shear stress, new imaging techniques, and endovascular treatment of MMD, along with practical applications and future directions for gene and stem cell therapies. For neurosurgeons as well as neurologists and pediatricians, this volume will help lead to more efficient and informed management of MMD.


MMD Moyamoya Disease PET SPECT anesthesia cerebrovascular disease cognition electroencephalography (EEG) magnetic resonance imaging (MRI) muscle neurosurgery pathophysiology positron emission tomography (PET) surgery surgical technique

Editors and affiliations

  • Byung-Kyu Cho
    • 1
  • Teiji Tominaga
    • 2
  1. 1.Department of NeurosurgerySeoul National University College of Medicine Seoul National University Children's HospitalJongno-guRepublic of Korea
  2. 2.Department of NeurosurgeryTohoku University Graduate School of MedicineAoba-kuJapan

Bibliographic information

  • Book Title Moyamoya Disease Update
  • Editors Byung-Kyu Cho
    Teiji Tominaga
  • DOI
  • Copyright Information Springer-Verlag Tokyo 2010
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-4-431-99702-3
  • Softcover ISBN 978-4-431-54649-8
  • eBook ISBN 978-4-431-99703-0
  • Edition Number 1
  • Number of Pages XX, 387
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurosurgery
  • Buy this book on publisher's site


From the reviews:

“This is an almost 400-page book on the current status of all things relating to Moyamoya disease (MMD) definition, etiology, status of research, diagnostic modalities, and treatment options. … Illustrative of all this material … are well done, sharp, and clear, with good legends and explanatory material. … Certainly, this is the definitive book for someone who wishes information on Moyamoya disease. It is quite complete, almost excessively so, and will undoubtedly remain a basic source for several years to come.” (Robert M. Arensman, Doody’s Review Service, June, 2010)

“Moyamoya Disease Update, edited by Cho and Tominaga, provides an excellent update of this recent progress and a comprehensive overview of all relevant aspects of the disease. … This book is an exciting and highly recommended update on moyamoya disease. In addition to the scientific and clinical information, the book clearly indicates that recent years have been substantial progress in our understanding of the disease.” (Peter Vajkoczy, The Lancet Neurology, Vol. 9, August, 2010)