© 2011

Mechanosensing Biology

  • Masaki Noda

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Cells and Signals

    1. Front Matter
      Pages 1-1
    2. Makoto Asashima, Yoshiro Nakajima, Yuzuru Ito, Tatsuo Michiue, Kiyoshi Ohnuma
      Pages 39-47
  3. Tissue and Gravity

    1. Front Matter
      Pages 49-49
    2. Yuushi Okumura, Takeshi Nikawa
      Pages 63-70
    3. Masaki Noda, Tadayoshi Hayata, Tetsuya Nakamoto, Takuya Notomi, Yoichi Ezura
      Pages 71-86
    4. Makoto Suzuki, Atsuko Mizuno
      Pages 87-101
  4. Skeletal Response

    1. Front Matter
      Pages 103-103
    2. Pierre J. Marie, Pierre J. Marie
      Pages 105-126
    3. Lynda Faye Bonewald
      Pages 141-155
    4. Toshio Matsumoto, Rika Kuriwaka-Kido, Shinsuke Kido
      Pages 157-166
    5. Akinori Sakai, Toshitaka Nakamura
      Pages 167-178
  5. Bone Signaling

    1. Front Matter
      Pages 179-179
    2. Géraldine Pawlak, Virginie Vives, Anne Blangy, Emmanuelle Planus, Corinne Albiges-Rizo
      Pages 193-213
  6. Back Matter
    Pages 215-219

About this book


Mechanical stress is vital to the functioning of the body, especially for tissues such as bone, muscle, heart, and vessels. It is well known that astronauts and bedridden patients suffer muscle and bone loss from lack of use. Even the heart, in pumping blood, causes mechanical stress to itself and to vascular tissue. With the loss of mechanical stress, homeostasis becomes impaired and leads to pathological conditions such as osteopenia, muscle atrophy, and vascular tissue dysfunction. In elderly populations, such mechanical pathophysiology, as well as the mechanical activities of locomotor and cardiovascular systems, is important because skeletal and heart functions decline and cause diseases in other organs. In this monograph, mechanical stress is discussed by experts in the field with respect to molecular, cellular, and tissue aspects in relation to medicine. Covering topics such as gravity and tissues and disuse osteoporosis, the book provides the most up-to-date information on cutting-edge advancements in the field of mechanobiology and is a timely contribution to research into locomotor and circulatory diseases that are major problems in contemporary society.

Editors and affiliations

  • Masaki Noda
    • 1
  1. 1.Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan

Bibliographic information