Hepatobiliary and Pancreatic Carcinogenesis in the Hamster

  • Yoshitsugu Tajima
  • Tamotsu Kuroki
  • Takashi Kanematsu

Table of contents

  1. Front Matter
    Pages i-xi
  2. General Information

    1. Yoshitsugu Tajima
      Pages 3-10
    2. Taiichiro Kosaka, Takehiro Mishima, Tomohiko Adachi
      Pages 11-15
    3. Takehiro Mishima, Tomohiko Adachi, Taiichiro Kosaka
      Pages 17-20
    4. Tomohiko Adachi, Taiichiro Kosaka, Takehiro Mishima
      Pages 21-26
  3. Experimental Carcinogenesis in the Hamster

    1. Yoshitsugu Tajima, Tomoo Kitajima, Tsutomu Tomioka, Toshifumi Eto, Keiji Inoue, Tomohiro Fukahori et al.
      Pages 29-68
    2. Yoshitsugu Tajima, Shizuo Yamanaka, Sumihiro Matsuzaki, Toshifumi Eto, Kazuya Okada, Hiroshi Shiku et al.
      Pages 69-94
    3. Tomoo Kitajima, Yoshitsugu Tajima, Kei Matsuo, Tamotsu Kuroki, Shinya Onizuka, Yoshito Ikematsu et al.
      Pages 95-103
    4. Tomoo Kitajima, Sumihiro Matsuzaki, Tamotsu Kuroki, Kenzo Fukuda, Yoshitsugu Tajima, Takashi Kanematsu
      Pages 105-114
    5. Yoshito Ikematsu, Tsutomu Tomioka, Tsukasa Tsunoda, Yoshitsugu Tajima, Takashi Kanematsu
      Pages 115-138
    6. Noritsugu Tsuneoka, Tamotsu Kuroki, Tomoo Kitajima, Kenzo Fukuda, Shinya Onizuka, Yoshitsugu Tajima et al.
      Pages 139-156
    7. Tomohiko Adachi, Yoshitsugu Tajima, Amane Kitasato, Noritsugu Tsuneoka, Ryuji Tsutsumi, Tamotsu Kuroki et al.
      Pages 157-170
    8. Tomohiko Adachi, Yoshitsugu Tajima, Tamotsu Kuroki, Takehiro Mishima, Amane Kitasato, Noritsugu Tsuneoka et al.
      Pages 171-181
  4. Cancer Lines and Biliary Epithelial Cell Lines

    1. Tomohiro Fukahori, Keiji Inoue, Tsutomu Tomioka, Yoshitsugu Tajima, Tsukasa Tsunoda, Takashi Kanematsu
      Pages 185-212
    2. Takayuki Asakawa, Amane Kitasato, Tsutomu Tomioka, Tamotsu Kuroki, Ryuji Tsutsumi, Yoshitsugu Tajima et al.
      Pages 213-235
  5. Back Matter
    Pages 237-241

About this book


Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.


Biliary Carcinoma Chemoprevention Experimental Carcinogenesis Hamster Pancreas Pancreatic Carcinoma carcinoma development tumorigenesis

Editors and affiliations

  • Yoshitsugu Tajima
    • 1
  • Tamotsu Kuroki
    • 1
  • Takashi Kanematsu
    • 1
  1. 1.Department of SurgeryNagasaki University Graduate School of Biomedical SciencesNagasakiJapan

Bibliographic information