Pancreatic Beta Cell in Health and Disease

  • Susumu Seino
  • Graeme I. Bell

Table of contents

  1. Front Matter
    Pages I-XV
  2. Pancreatic Beta Cell and Insulin Biosynthesis

    1. Front Matter
      Pages 1-1
    2. Marcela Brissova, Alvin C. Powers
      Pages 3-11
    3. Isabella Artner, Roland Stein
      Pages 13-30
    4. Donald F. Steiner
      Pages 31-49
  3. Cell Signaling and Insulin Secretion

    1. Front Matter
      Pages 51-51
    2. Barbara E. Corkey
      Pages 53-74
    3. Marc Y. Donath, Jan A. Ehses
      Pages 75-89
    4. David A. Jacobson, Louis H. Philipson
      Pages 91-110
    5. Philippe Klee, Sabine Bavamian, Anne Charollais, Dorothée Caille, José Cancela, Manon Peyrou et al.
      Pages 111-132
    6. Susumu Seino, Takashi Miki, Tadao Shibasaki
      Pages 133-146
    7. Erik Renström, Patrik Rorsman
      Pages 147-176
    8. Shinya Nagamatsu, Mica Ohara-Imaizumi
      Pages 177-193
    9. Noriko Takahashi, Haruo Kasai
      Pages 195-211
  4. Pancreatic Development and Beta-Cell Formation

    1. Front Matter
      Pages 213-213
    2. Christopher J. Rhodes
      Pages 215-243
    3. Seth J. Salpeter, Yuval Dor
      Pages 245-263
    4. Timo Otonkoski, Meenal Banerjee, Karolina Lundin
      Pages 265-284
  5. Incretins and Beta-Cell Function

    1. Front Matter
      Pages 313-313
    2. Sonia Klinger, Bernard Thorens
      Pages 315-334
    3. Michael A. Nauck, Juris J. Meier
      Pages 335-378
  6. Pancreatic Beta Cell and Disease

  7. Back Matter
    Pages 465-474

About this book


The beta cells of the pancreatic islets of Langerhans are the only cells in the body that produce and secrete insulin, a key metabolic hormone, which plays a central role in the maintenance of glucose homeostasis regulating glucose uptake in muscle and adipose tissue as well as carbohydrate, fat, and protein metabolism in these tissues and the liver. Failure of normal beta-cell function can lead to hyperglycemia (diabetes mellitus) or hypoglycemia. While hy- glycemia is a rare and life-threatening condition in which the beta cell secretes too much insulin, diabetes mellitus is a common disorder that is fast bec- ing an epidemic. It is a major threat to human health in the 21st century. The number of diabetic patients worldwide is rapidly increasing and is predicted to reach 380 million by 2025, according to the International Diabetes Fede- tion (IDF). Diabetes mellitus is a heterogeneous disorder with some forms such as maturity-onset diabetes of the young and permanent neonatal diabetes being primary genetic disorders of the beta cell. Monogenic forms of diabetes are an uncommon cause of diabetes representing about 1% of cases. The common forms of diabetes mellitus, designated type 1 and type 2, are multifactorial in origin with both genetic and environmental factors contributing to their development. Type 1 diabetes is caused by autoimmune destruction of beta cells leading to an absolute de? ciency of insulin and fatal hyperglycemia and ketoacidosis if not treated.


Diabetes Insulin Secretion Islets Of Langerhans Pancreatic Islets biosynthesis cell cells development genetic disorders homeostasis insulin protein regulation stem cells tissue

Editors and affiliations

  • Susumu Seino
    • 1
  • Graeme I. Bell
    • 2
  1. 1.Division of Cellular and Molecular Medicine, Department of Physiology and Cell BiologyKobe University Graduate School of MedicineKobeJapan
  2. 2.Medicine and Human GeneticsThe University of ChicagoChicagoUSA

Bibliographic information