How the Immune System Recognizes Self and Nonself

Immunoreceptors and Their Signaling

  • Daisuke Kitamura

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Satoshi Uematsu, Shizuo Akira
    Pages 1-36
  3. Hiromi Kubagawa, Ching-Cheng Chen, Ikuko Torii, Max D. Cooper, Kyoko Masuda, Yoshimoto Katsura et al.
    Pages 83-98
  4. Catherine Mazza, Bernard Malissen
    Pages 133-171
  5. Falk Nimmerjahn, Jeffrey V. Ravetch
    Pages 173-198
  6. Helga Schneider, Christopher E. Rudd
    Pages 221-245
  7. Back Matter
    Pages 247-251

About this book


How do you discriminate yourself from other people? This question must sound odd to you since you easily recognize others at a glance and, without any effort, would not mistake them for yourself. However, it is not always easy for some people to discriminate themselves from others. For example, patients with schi- phrenia often talk with “others” living inside themselves. Thus it is likely that n- mally your brain actively recognizes and remembers the information belonging to yourself and discriminates it from the information provided by others, although you are not conscious of it. This brain function must have been particularly important for most animals to protect their lives from enemies and for species to survive through evolution. Similarly, higher organisms have also acquired their immune system through evolution that discriminates nonself pathogens and self-body to protect their lives from pathogens such as bacteria or viruses. The brain system may distinguish integrated images of self and nonself created from many inputs, such as vision, sound, smell, and others. The immune system recognizes and distinguishes a variety of structural features of self and nonself components. The latter actually include almost everything but self: for example, bacteria, viruses, toxins, pollens, chemicals, transplanted organs, and even tumor cells derived from self-tissue. To this end the immune system recruits different kinds of immune cells, such as B and T lymphocytes, natural killer (NK) cells, dendritic cells, and macrophages.


Viruses autoimmune disease bacteria cell diseases immune system immunity immunoglobulin infection lymphocytes membrane protein regulation tissue tumors

Editors and affiliations

  • Daisuke Kitamura
    • 1
  1. 1.Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Division of Molecular Biology, Research Institute for Biological SciencesTokyo University of ScienceChibaJapan

Bibliographic information