Advances in Osteoarthritis

  • Seisuke Tanaka
  • Chiaki Hamanishi
Conference proceedings

Table of contents

  1. Front Matter
    Pages II-X
  2. Mechanical Stress and Chondrocyte Reactions

    1. Front Matter
      Pages 1-1
    2. Jyrki J. Parkkinen, Mikko J. Lammi, Matti O. Jortikka, Ritva I. Inkinen, Kai Kaarniranta, Heikki J. Helminen et al.
      Pages 21-34
    3. Kanji Fukuda, Shigeki Asada, Kazuhiro Otani, Chiaki Hamanishi, Seisuke Tanaka
      Pages 35-47
  3. Functional Diagnosis of Osteoarthritis

    1. Front Matter
      Pages 57-57
    2. Steven Treppo, Scott I. Berkenblit, David L. Bombard, Eliot H. Frank, Alan J. Grodzinsky
      Pages 59-73
    3. Charles G. Peterfy
      Pages 74-92
    4. Toshikazu Kubo, Yuji Arai, Kappei Kobayashi, Jiro Imanishi, Masaharu Takigawa, Yasusuke Hirasawa
      Pages 107-118
  4. New Cartilage Markers

    1. Front Matter
      Pages 119-119
    2. Johanne Martel Pelletier, Jean-Pierre Pelletier
      Pages 121-133
    3. Katsuji Shimizu
      Pages 134-141
  5. Promising Treatments 1

    1. Front Matter
      Pages 151-151
    2. S. W. Brostoff, D. J. Carlo, J. P. Diveley, E. E. Morgan, C. J. Nardo, S. P. Richieri et al.
      Pages 153-162
    3. Elizabeth O’Byrne, Vincent Blancuzzi, Hem Singh, Lawrence J. MacPherson, David T. Parker, E. Donald Roberts
      Pages 163-173
  6. Promising Treatments 2: Cartilage Repair

    1. Front Matter
      Pages 185-185
    2. Ernst B. Hunziker
      Pages 187-202
    3. Richard H. Edelson
      Pages 203-212
    4. Hiraku Kikuchi, Tohgo Nonaka, Wataru Shimada, Ichiro Miyagi, Hiroaki Itagane, Terumasa Ikeda et al.
      Pages 237-250
  7. Problems Following Total Joint Replacement

    1. Front Matter
      Pages 251-251
    2. Robin J. E. D. Higgs, William A. J. Higgs
      Pages 253-270
    3. Bassam A. Masri, Eduardo A. Salvati, Clive P. Duncan
      Pages 271-285
  8. Back Matter
    Pages 297-298

About these proceedings


Basic research on osteoarthritis has been carried out mainly from the his­ tological and biochemical aspects of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical stress has been shown to be the principal factor in the initiation of osteoarthritis. Although the exact process by which mechanical stress leads to the total destruction of cartilage tissue remains unclear, several new research methods have enabled us to gain a deeper understanding of the process of degeneration. In October 1997, we organized an international symposium titled "Ad­ vances in Osteoarthritis" in Kobe, with the main topics being updated re­ search, diagnosis, and treatment of osteoarthritis. The proceedings of the symposium are presented here in five sections: (1) Mechanical stress and reactions of chondrocytes, such as intracellular ion changes, changes in the cytoskeleton, intracellular messenger systems, release of gas mediators, and changes in electromechanical properties of cartilage; (2) Functional diagnosis of osteoarthritis by MR imaging, and using calpain and collagenase III as new cartilage markers; (3) Treatment with a promising simple washout technique and IL-1RA and MMP antagonists; (4) Cartilage repair by new grafting tech­ niques; and (5) Problems following total joint replacement. We sincerely hope that the advanced knowledge provided in this volume of proceedings will be valuable to our readers.


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Editors and affiliations

  • Seisuke Tanaka
    • 1
  • Chiaki Hamanishi
    • 2
  1. 1.Kinki University School of MedicineOsakaJapan
  2. 2.Department of Orthopedic SurgeryKinki University School of MedicineOsakaJapan

Bibliographic information