Advertisement

Protection Against Ischemia/Reperfusion Damage of the Heart

  • Yasushi Abiko
  • Morris Karmazyn

Table of contents

  1. Front Matter
    Pages II-IX
  2. Modulators of Ischemia/Reperfusion Damage H+, Na+, and Ca2+

    1. Front Matter
      Pages 1-1
    2. Munekazu Shigekawa, Toshitaro Ikeda, Takahiro Iwamoto, Shigeo Wakabayashi
      Pages 3-21
    3. Roberta A. Gottlieb, Robert L. Engler
      Pages 23-37
  3. Modulators of Ischemia/Reperfusion Damage: Lipid Metabolites

    1. Front Matter
      Pages 63-63
    2. Hiroko Hashizume, Min Chen, Hong Ma, Nina Hoque, Akiyoshi Hara, Kazuto Yazawa et al.
      Pages 75-87
    3. Ger J. Van der Vusse, Leon J. de Windt, Sylvia W. S. Jans, Robert S. Reneman, Marc van Bilsen
      Pages 89-114
    4. Haruaki Nakaya, Seiichi Yamaguchi, Ikumi Sakashita, Nobuyuki Nakajima
      Pages 115-127
  4. Molecular Mechanisms of Myocardial and Vascular Remodeling in the Ischemic Heart

    1. Front Matter
      Pages 129-129
    2. Hideaki Kawaguchi, Akira Kitabatake
      Pages 131-145
    3. Toshimitsu Uede, Yohko Katagiri, Hiroshi Hotta, Kumiko Tanaka, Junko Iizuka
      Pages 147-156
    4. Akira Matsumori, Koh Ono, Shigetake Sasayama
      Pages 157-177
  5. New Therapeutic Strategy to Attenuate Ischemia/Reperfusion Damage

    1. Front Matter
      Pages 193-193
    2. Satoshi Takeo, Kouichi Tanonaka, Jian-Xun Liu, Toru Kamiyama, Itaru Ohoi, Hiroshi Kajiwara et al.
      Pages 195-214
    3. Kazuo Ichihara, Kumi Satoh, Tohru Nakai
      Pages 215-227
    4. Fumio Yamamoto, Junjiro Kobayashi, Hiroaki Sasaki, Yoshiaki Suematsu, Yutaka Hino, Jun Okawara et al.
      Pages 229-241
  6. Back Matter
    Pages 243-248

About this book

Introduction

How to protect against ischemia/reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage-producing mechanism is not yet fully understood. This book provides the latest information on the pathophysiology of ischemia/reperfusion damage and presents new ideas for more effective methods for protection. In the first two sections, the roles of such factors as various ions and phospholipids that modulate ischemia/reperfusion damage are explored, providing a clear and updated explanation of the mechanisms involved. In the third section, the myocardial and vascular remodeling procedure in hearts that have undergone ischemia/reperfusion is explained in terms of signal transduction, enabling a new understanding of the remodeling process. In the final section, a new approach to protection against ischemia/reperfusion damage is presented.

Keywords

Drogen cardiovascular cytokine drugs growth factor heart lipide pathophysiology physiology

Editors and affiliations

  • Yasushi Abiko
    • 1
  • Morris Karmazyn
    • 2
  1. 1.Department of PharmacologyAsahikawa Medical CollegeAsahikawaJapan
  2. 2.Department of Pharmacology and ToxicologyThe University of Western OntarioLondonCanada

Bibliographic information