Malignant Hyperthermia

Proceedings of the 3rd International Symposium on Malignant Hyperthermia, 1994

  • Michio Morio
  • Hirosato Kikuchi
  • Osafumi Yuge
Conference proceedings

Table of contents

  1. Front Matter
    Pages II-XV
  2. History of Malignant Hyperthermia

    1. Front Matter
      Pages 1-1
    2. Beverley A. Britt
      Pages 3-17
  3. Clinical Classification and Incidence of Fulminant and Abortive Malignant Hyperthermia

    1. Front Matter
      Pages 19-19
    2. Helle Ørding, Diana Bendixen
      Pages 21-24
    3. Dorrit Heilinger, Eva Donner, Andrea Sauberer, Werner Hackl, Walter Mauritz
      Pages 25-32
    4. V. Tegazzin, A. Accorsi, I. Moroni, D. Di Martino, V. Brancadoro, V. Peduto
      Pages 33-37
    5. Marilyn Green Larach, Linda J. Fuhrmann, Gregory C. Allen
      Pages 39-41
    6. Osafumi Yuge, Michio Morio, Hirosato Kikuchi, Keiko Mukaida, Yasuhiro Maehara, Masakazu Nakao et al.
      Pages 49-56
  4. Muscular Testing of Malignant Hyperthermia

    1. Front Matter
      Pages 57-57
    2. Akio Takagi, Makoto Araki, Susumu Kojima, Masayoshi Ida, Tomoji Watanabe
      Pages 67-73
    3. Makoto Endo
      Pages 75-75
  5. Genetic Study of Malignant Hyperthermia

    1. Front Matter
      Pages 77-77
    2. Gary M. Vita, Antonel Olckers, Anne E. Jedlicka, Terry Heiman-Patterson, Alfred L. George, Jeffery E. Fletcher et al.
      Pages 87-93
    3. J. Paul Mounsey, Puting Xu, J. Edward John III, John Gilbert, Allen D. Roses, J. Randall Moorman
      Pages 95-101
  6. Biological Study of Malignant Hyperthermia

  7. Malignant Hyperthermia Related Syndromes

    1. Front Matter
      Pages 145-145
    2. Beverley A. Britt, C. Anne Mildon, Wanda Frodis, Elizabeth Scott
      Pages 147-158
    3. Gerald A. Gronert
      Pages 159-161
    4. Khay S. Cheah
      Pages 163-171
    5. Thomas E. Nelson
      Pages 173-182
    6. Koh Shingu, Kenjiro Mori
      Pages 183-186
    7. P. J. Adnet, N. Bello, H. Reyford, R. M. Krivosic-Horber
      Pages 197-202
    8. Frank Lehmann-Horn
      Pages 203-210
  8. Therapy of Malignant Hyperthermia

    1. Front Matter
      Pages 211-211
    2. Uwe Schulte-Sasse
      Pages 213-217
  9. Free Discussion

    1. Front Matter
      Pages 219-219
    2. Michio Morio, Hirosato Kikuchi, Osafumi Yuge
      Pages 221-244
  10. Back Matter
    Pages 245-256

About these proceedings


In susceptible individuals, malignant hyperthermia (MH) can be triggered by various anesthetics during surgery. First described in 1960, research since then has concentrated on reducing the very high mortality rate associated with MH. Although significant progress in treatment has been made with the introduction of dantrolene sodium in 1979, many questions remain unanswered. Following on the results of more than 30 years of investigative efforts, the Third International Symposium on MH was held in Hiroshima, Japan, in 1994, immediately before the Seventh International Workshop on MH. Specialists in the field discussed the most up-to-date findings from the point of view of clinical classification, history, and incidence based on the evidence of epidemiology, diagnostic muscle testing, genetics, and biochemistry. These proceedings of the symposium present important keys to understanding the mechanism of MH and related syndromes at the genetic level and include procedures for the monitoring and care of patients. This volume will be invaluable not only for surgeons and anesthesiologists but also for physiologists and researchers.


Etiology Malignant Hyperthermia Treatment biochemistry care classification genetics monitoring mortality muscle pain patients research surgery syndromes

Editors and affiliations

  • Michio Morio
    • 1
  • Hirosato Kikuchi
    • 2
  • Osafumi Yuge
    • 3
  1. 1.Chugoku Rosai General HospitalHiroshima UniversityKure, HiroshimaJapan
  2. 2.The First Department of AnesthesiologyToho University School of MedicineOhta-ku, Tokyo, 143Japan
  3. 3.Department of Anesthesiology and Critical Care MedicineHiroshima University School of MedicineHiroshima, 734Japan

Bibliographic information