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Liver Cirrhosis

  • Kiwamu Okita
Conference proceedings

Table of contents

  1. Front Matter
    Pages II-XII
  2. Henning Wege, Jian Wu, Mark A. Zern
    Pages 17-29
  3. Takato Ueno, Toru Nakamura, Hikaru Ueno, Kyuichi Tanikawa, Michio Sata
    Pages 36-43
  4. Kozo Kayano, Isao Sakaida, Kiwamu Okita
    Pages 44-55
  5. Takeshi Okanoue, Yoshiki Murakami, Masahito Minami, Yoshito Itoh
    Pages 65-72
  6. Shuichi Hirono, Kenji Nagata, Akihiro Ivioriuchi, Masaaki Onaga, Himiko Fujiwara, Takeshi Hori et al.
    Pages 87-92
  7. Eiji Miyoshi, Katsuhisa Noda, Naoyuki Taniguchi, Yutaka Sasaki, Norio Hayashi
    Pages 93-104
  8. Hisataka Moriwaki, Masahiro Tajika, Yoshiyuki Miwa, Masahiko Kato
    Pages 105-111
  9. Back Matter
    Pages 123-125

About these proceedings

Introduction

Since 1998, the Japanese Society of Hepatology has campaigned to fight hepatocellu­ lar carcinoma (HCC). Because the mortality rate for this disease has reached more than 30 per 100,000 population, the organizing committee chose HCC as the main topic of the 1999 Yamaguchi Symposium on Liver Diseases. Regarding hepatocar­ cinogenesis, we know that HCC often develops secondary to liver cirrhosis; thus liver cirrhosis must be recognized as a prevalent pathological condition leading to HCC. If we can control liver fibrosis, we can reduce the risk for HCC among patients with chronic hepatitis. To achieve this goal, we must know more about hepatic fibrosis. Professor Michael J. P. Arthur is familiar as a leading scientist in this field. We were fortunate that he accepted our invitation to speak. His lecture titled "Mechanisms of the Progression and Regression of Liver Fibrosis" provided important advice for developing antifibrotic agents. We also invited Professor Mark A. Zern, who has been studying hepatic fibrosis for some time. In the symposium he talked about novel approaches, including gene therapy, to treat acute and chronic hepatic diseases in the 21st century. In addition to the informative talks by those guests from abroad, the lecture by Dr. J. Fujimoto was very impressive. He revealed that gene therapy using hepatocyte growth factor (HGF) could inhibit progression to liver cirrhosis in rats repeatedly injected with dimethylnitrosamine (DMN). Dr. Fujimoto has already pub­ lished his finding that administration of HGF reduced hepatocarcinogenesis in rats.

Keywords

Hepatic fibrosis Hepatic stellate cell Hepatocarcinogenesis hepatitis hepatology liver liver disease

Editors and affiliations

  • Kiwamu Okita
    • 1
  1. 1.First Department of Internal MedicineYamaguchi University School of MedicineUbe, YamaguchiJapan

Bibliographic information