Functional Adaptation and Remodeling

  • Kozaburo Hayashi
  • Akira Kamiya
  • Keiro Ono

Table of contents

  1. Front Matter
    Pages II-IX
  2. Response of Endothelial Cells to Mechanical Stress

    1. Front Matter
      Pages 1-1
    2. Masaaki Sato, Noriyuki Kataoka, Norio Ohshima
      Pages 3-27
  3. Functional Adaptation and Optimal Control of the Heart and Blood Vessels

    1. Front Matter
      Pages 57-57
    2. Hitonobu Tomoike
      Pages 59-75
    3. Hiroyuki Abé, Satoru Goto, Teruo Kimura, Hidetsugu Kushibiki, Shigeru Arai
      Pages 77-91
    4. Takeo Matsumoto, Kozaburo Hayashi
      Pages 93-119
  4. Tissue Remodeling and Biomechanical Response in Orthopedics and Orthodontics

    1. Front Matter
      Pages 121-121
    2. Juhachi Oda, Jiro Sakamoto, Kazuhiro Aoyama, Yasunobu Sueyoshi, Katsuro Tomita, Takeshi Sawaguchi
      Pages 123-140
    3. Masafumi Morita, Tadashi Sasada
      Pages 141-167
    4. Kozaburo Hayashi, Noritaka Yamamoto, Kazunori Yasuda
      Pages 185-212
    5. Kazunori Yasuda, Kozaburo Hayashi
      Pages 213-250
    6. Sohei Ebara, Takeo Harada, Takenori Oda, Eiji Wada, Shimpei Miyamoto, Kazuo Yonenobu et al.
      Pages 251-282
    7. Shinji Nakamura, Hiroyuki Ishikawa, Yoshiaki Satoh, Tomoo Kaneko, Naoyuki Takahashi, Minoru Wakita
      Pages 283-305
  5. Back Matter
    Pages 307-314

About this book


"Function dictates structure" is a classic paradigm reaffirmed in Wolff's law of the skeletal system. A major question being addressed by current research in biomechanics is whether this doctrine also holds true for the cardiovascular system and connective tissues. Taking a multidisciplinary approach to this question has produced new insights into the sensors, signals, and activators that produce remodeling and functional adaptation in cardiac muscle, blood vessels, and bone, including important new findings on the response of vascular endothelial cells to shear stress. Other work focuses on the extent of remodeling and adaptation processes in tendons, ligaments, and intervertebral discs. Together with two companion volumes, Computational Biomechanics and the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs, this monograph will prove invaluable to those working in fields ranging from medical science and clinical medicine to biomedical engineering and applied mechanics.


adaptation biomechanics biomedical engineering blood vessel bone cardiovascular system cells endothelium fracture instability knee mechanics medicine orthopedics tissue

Editors and affiliations

  • Kozaburo Hayashi
    • 1
  • Akira Kamiya
    • 2
  • Keiro Ono
    • 3
  1. 1.Department of Mechanical Engineering, Faculty of Engineering ScienceOsaka UniversityToyonaka, Osaka, 560Japan
  2. 2.Institute of Medical ElectronicsUniversity of Tokyo School of Medicine7-3-1 Hongo ,Bunkyo-ku, Tokyo, 113Japan
  3. 3.Osaka Koseinenkin Hospital4-2-78 Fukushima ,Fukushima-ku, Osaka, 553Japan

Bibliographic information