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Lessons for Science from the Seven Countries Study

A 35-Year Collaborative Experience in Cardiovascular Disease Epidemiology

  • Ancel Keys
  • Hironori Toshima
  • Yoshinori Koga
  • Henry Blackburn

Table of contents

  1. Front Matter
    Pages III-XII
  2. Overview of the Seven Countries Study

  3. Update on the Seven Countries Study

    1. Front Matter
      Pages 15-15
    2. Alessandro Menotti, Fulvia Seccareccia
      Pages 17-33
    3. Daan Kromhout, Bennie P. M. Bloemberg
      Pages 35-41
    4. Aulikki Nissinen, Paula Kivinen, Edith Feskens, Simona Giampaoli, Daan Kromhout, Alessandro Menotti et al.
      Pages 43-51
    5. Flaminio Fidanza, Adalberta Alberti Fidanza
      Pages 53-59
  4. Recent Trends in Cardiovascular Diseases and Risk Factors in the Seven Countries Study

    1. Front Matter
      Pages 61-61
    2. Yoshinori Koga, Ryuichi Hashimoto, Hisashi Adachi, Makoto Tsuruta, Hiromi Tashiro, Hironori Toshima
      Pages 63-74
    3. Srecko I. Nedeljković, Miodrag Č. Ostojić, Milija R. Vukotić, Miodrag Z. Grujić
      Pages 75-91
    4. W. M. Monique Verschuren, Henriette A. Smit, Edith M. Van Leer, Jacob C. Seidell, Daan Kromhout
      Pages 127-144
    5. David R. Jacobs Jr., J. Michael Sprafka, Peter J. Hannan, Cynthia M. Ripsin, Paul G. McGovern, Henry Blackburn
      Pages 145-161
    6. Juha Pekkanen, Antti Uutela, Tapani Valkonen, Erkki Vartiainen, Jaakko Tuomilehto, Pekka Puska
      Pages 163-175
  5. Lessons from the Seven Countries Study

    1. Front Matter
      Pages 177-177
    2. Henry Blackburn
      Pages 235-235
  6. Back Matter
    Pages 237-243

About these proceedings

Introduction

The Seven Countries Study has made central contributions to the under­ standing of the socio-cultural influences on population rates of cardiovascular diseases (CVD). It has pointed the way to preventive strategies for whole populations. The Study is unique as a long-term investigation, now in its 35th year. This pioneering work arose in part from a meeting between Professors Ancel Keys and Noboru Kimura to discuss differences observed in clinical mani­ festations and pathology of coronary disease in the U.S. and Japan. Professor Keys started explorations of the importance in these differences of dietary fat and serum cholesterol when he visited Japan in 1954, and thereafter initiated the Seven Countries Study to test these hypotheses. In the Japanese cohorts of the Study, it became evident from the outset that coronary artery disease was extremely rare, but its incidence has since increased along with dramatic lifestyle changes from traditional Japanese to western styles. The Japanese experience contrasts with a reduction in coronary artery disease in many western countries along with establishment of major preventive efforts in risk factor reduction and cardiac care.

Keywords

Cardiovascular Disease Epidemiology Coronary Risk Factors Seven Countries Study cardiovascular epidemiology health vascular disease

Editors and affiliations

  • Ancel Keys
    • 1
  • Hironori Toshima
    • 2
  • Yoshinori Koga
    • 3
  • Henry Blackburn
    • 1
  1. 1.Division of Epidemiology, School of Public HealthUniversity of MinnesotaUSA
  2. 2.The Third Department of Medicine, The Institute of Cardiovascular DiseasesKurume University School of MedicineKurumeJapan
  3. 3.The Third Department of MedicineKurume University School of MedicineKurumeJapan

Bibliographic information