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The Genetics of Complex Thyroid Diseases

  • Takashi Akamizu
  • Masato Kasuga
  • Terry F. Davies
Conference proceedings

Table of contents

  1. Front Matter
    Pages II-XI
  2. Autoimmune Thyroid Diseases

  3. Familial Thyroid Cancers

    1. Front Matter
      Pages 137-137
    2. Orlo H. Clark
      Pages 139-150
    3. Bryan McIver, Norman L. Eberhardt
      Pages 151-175
    4. Massimo Santoro, Francesca Carlomagno, Rosa Marina Melillo, Giancarlo Vecchio, Alfredo Fusco
      Pages 176-183
    5. Shunichi Yamashita, Hiroyuki Namba, Noboru Takamura, Kiyoto Ashizawa, Yoshisada Shibata
      Pages 184-197
    6. Yuri E. Nikiforov
      Pages 198-219
  4. Back Matter
    Pages 220-222

About these proceedings

Introduction

The rapid developments in molecular genetics have clarified many of the muta­ tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method­ ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis­ ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup­ ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con­ cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin­ guished researchers from the United States, the United Kingdom, France, Ger­ many, Italy, and Japan were invited. Each presentation precipitated intense dis­ cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know.

Keywords

Chromosom Diabetes Graves's disease Hashimoto's thyroiditis Termination autoimmune thyroid disease familial thyroid-cancer genes genetics molecular mechanisms

Editors and affiliations

  • Takashi Akamizu
    • 1
  • Masato Kasuga
    • 2
  • Terry F. Davies
    • 3
  1. 1.Department of Medicine and Clinical ScienceKyoto University Graduate School of MedicineSakyo-ku, KyotoJapan
  2. 2.Department of Internal MedicineKobe University School of MedicineChuo-ku, KobeJapan
  3. 3.Division of Endocrinology and MetabolismMount Sinai School of MedicineNew YorkUSA

Bibliographic information