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Table of contents

  1. Front Matter
    Pages II-XVIII
  2. Overview of Paroxysmal Nocturnal Hemoglobinuria

  3. Pathogenesis and Animal Models of PNH

    1. Front Matter
      Pages 25-25
    2. Russell E. Ware, Matthew M. Heeney, Chrisley V. Pickens, Carlos M. DeCastro, Thad A. Howard
      Pages 41-53
  4. Clinical Pathology and Natural History of PNH

  5. Mechanism of Clonal Expansion in PNH

    1. Front Matter
      Pages 95-95
    2. Hideki Nakakuma, Tatsuya Kawaguchi
      Pages 97-103
    3. Lucio Luzzatto, Anastasios Karadimitris, David Araten, Rosario Notaro
      Pages 105-116
    4. Norimitsu Inoue, Tomohisa Izui, Maki Kuwayama, Jun-ichi Nishimura, Ken Kurokawa, Takashi Machii et al.
      Pages 117-126
  6. PNH Clones Under Bone Marrow Failure

    1. Front Matter
      Pages 127-127
    2. Masao Tomonaga, Masako Iwanaga, Kengo Fuchigami, Yoriko Inoue, Tatsuro Joh, Itsuro Jinnai
      Pages 139-148
    3. Neal S. Young, Jaroslaw P. Maciejewski, Elaine Sloand, Guiben Chen, Weihua Zeng, Antonio Risitano et al.
      Pages 149-158
  7. PNH, Aplastic Anemia, Myelodysplastic Syndromes (1): Pathology

    1. Front Matter
      Pages 159-159
    2. E. C. Gordon-Smith
      Pages 161-166
    3. André Tichelli, Gérard Socié
      Pages 179-195
  8. PNH, Aplastic Anemia, Myelodysplastic Syndromes (2): Clinical Aspects

    1. Front Matter
      Pages 197-197
    2. Andrea Bacigalupo, Rosi Oneto, Barbara Bruno, Hubert Schrezenmeier on behalf of the working party on severe aplastic anemia (WPSAA) of the European Blood and Marrow Transplantation group (EBMT)
      Pages 211-217
  9. Related Topics

    1. Front Matter
      Pages 219-219
    2. J H Yoon, H I Cho, S S Park, Y H Chang, B K Kim
      Pages 221-224
    3. Yoshiko Murakami, Hiroshi Kosaka, Junji Takeda, Taroh Kinoshita
      Pages 225-227
    4. Wanachiwanawin W, Piyawattanasakul N, Visuthisakchai S, Issaragrisil S
      Pages 229-233
    5. Jun-ichi Nishimura, Yuzuru Kanakura, Russell E. Ware, Tsutomu Shichishima, Hideki Nakakuma, Haruhiko Ninomiya et al.
      Pages 235-237
    6. Jun-ichi Nishimura, Yuzuru Kanakura, Russell E. Ware, Tsutomu Shichishima, Hideki Nakakuma, Haruhiko Ninomiya et al.
      Pages 239-241
    7. Toshiyuki Hirota, Jun-ichi Nishimura, Yuzuru Kanakura, Takashi Machii, Maki Kuwayama, Norimitsu Inoue et al.
      Pages 243-246
    8. Wouter Hazenbos, Irmgard Förster, Björn Clausen, Junji Takeda, Taroh Kinoshita
      Pages 247-249
    9. Hiroshi Harada, Hiraku Mori, Haruo Niikura, Mitsuhiro Omine
      Pages 251-254
    10. Ayami Yoshimi, Yoshiyuki Takahashi, Kazuko Kudo, Seiji Kojima
      Pages 255-258
    11. Kensuke Usuki, Akiko Furuya, Yuji Hirai, Seiko Iki, Akio Urabe
      Pages 259-262
    12. Takahiro Okamoto, Masaya Okada, Ako Mori, Hiroyuki Takatsuka, Yoshihiro Fujimori, Eizo Kakishita
      Pages 263-269
    13. Takeshi Yasunami, Masanao Teramura, Koij Iwabe, Michihiko Masuda, Toshiko Motoji, Hideaki Mizoguchi
      Pages 271-274
    14. Chikashi Yoshida, Yasushi Ohkoshi, Yuichi Hasegawa, Toshiro Nagasawa, Haruhiko Ninomiya
      Pages 275-278
  10. Back Matter
    Pages 283-285

About these proceedings

Introduction

Few publications focus on the mysterious, genetically acquired disease paroxysmal nocturnal hemoglobinuria (PNH) and the related "intractable" disorders—aplastic anemia and myelodysplastic syndromes. Now, however, the latest understanding of the clinical and molecular genetic aspects of PNH is summarized here in the proceedings of the International Symposium held in Tokyo in 2001. Major topics reviewed include the molecular mechanisms of the PIG-A gene mutation; complement activation and inhibitors; experimental animal models; pathogenesis; the history of PNH research; the natural history of the disease; the mechanism of PNH clone expansion; the emergence of PNH clones under bone marrow failure syndromes; and treatment of the disease by immunosuppressive agents and stem cell transplantation. This book provides an invaluable summary of current research on the fundamental aspects of PNH pathology, presented by renowned experts in the field.

 

Keywords

anemia blood bone marrow stem cell transplantation transplantation

Editors and affiliations

  • Mitsuhiro Omine
    • 1
  • Taroh Kinoshita
    • 2
  1. 1.Division of HematologyInternal Medicine Showa University Fujigaoka HospitalAoba-ku, YokohamaJapan
  2. 2.Department of ImmunoregulationResearch Institute for Microbial Diseases Osaka UniversitySuita, OsakaJapan

Bibliographic information