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Molecular and Cellular Mechanisms of Cardiovascular Regulation

  • Masao Endoh
  • Martin Morad
  • Hasso Scholz
  • Toshihiko Iijima

Table of contents

  1. Front Matter
    Pages II-XVIII
  2. Molecular Mechanisms of Ion-Channel Regulation

    1. Front Matter
      Pages 1-1
    2. Norio Taira, Kuniaki Ishii
      Pages 3-13
    3. Naohiko Takahashi, Ken-Ichirou Morishige, Mitsuhiko Yamada, Chikako Kondo, Yoshihisa Kurachi
      Pages 59-67
    4. Masayasu Hiraoka, Tetsushi Furukawa, Tohru Sawanobori, Teiichi Yamane
      Pages 83-91
    5. Ulrich Quast, Claudia Linde, Cornelia Löffler, Friedrich Metzger
      Pages 111-121
  3. Mechanisms of Vascular Regulation

    1. Front Matter
      Pages 123-123
    2. Théophile Godfraind, Nicole Morel, Olivier Feron, Chantal Dessy, Salvatore Salomone
      Pages 125-147
    3. Hiroyoshi Hidaka, Yukio Kimura
      Pages 169-181
    4. Hideaki Karaki, Fujio Abe, Minori Mitsui-Saito, Satoshi Kitajima, Ken-Ichi Harada, Masatoshi Hori et al.
      Pages 195-210
  4. Mechanisms of Cardiac Regulation

    1. Front Matter
      Pages 219-219
    2. Franz Hofmann, Norbert Klugbauer, Lubica Lacinová, Claudia Seisenberger, Angela Schuster, Andrea Welling
      Pages 231-242
    3. Michihiko Tada, Toshihiko Toyofuku
      Pages 255-267
    4. Jessica Grossman, Thomas Hampton, Jianxun Wang, Zhihua Qiu, James Morgan
      Pages 269-280
    5. Jean-Luc Balligand, Xinqiang Han, William W. Simmons, David M. Kaye, Wendy L. Gross, Ralph A. Kelly et al.
      Pages 353-362
    6. Hiroyuki Suga, Miyako Takaki, Hiromi Matsubara, Junichi Araki
      Pages 373-389
  5. Pathophysiological Modulation of Regulatory Mechanisms

    1. Front Matter
      Pages 391-391
    2. Ichiro Shiojima, Tsutomu Yamazaki, Issei Komuro, Ryozo Nagai, Yoshio Yazaki
      Pages 409-415
    3. Masatsugu Hori, Masafumi Kitakaze, Takenobu Kamada
      Pages 417-432
    4. Shigetake Sasayama, Akira Matsumori, Sigeo Matsui, Tetsuo Shioi, Takehiko Yamada
      Pages 433-443
  6. Back Matter
    Pages 445-452

About these proceedings

Introduction

This volume contains selected papers presented at the Sendai International Sympo­ sium on Molecular and Cellular Mechanisms of Cardiovascular Regulation held from May 10-12, 1995, to honor the contributions ofProfessorNorio Taira, Chairman of the Department of Pharmacology (1972-1995), Tohoku University School of Medicine, Sendai, Japan. The Department of Pharmacology at Sendai has a long tradition of significant contribution to the development of drug therapy for cardiovascular diseases. The late Professor Koroku Hashimoto, the predecessor of Professor Norio Taira, first suggested the mode of action of calcium antagonists and their potential usefulness in therapy of ischemic heart disease and hypertension at an early stage of their development. The need for greater understanding of the pathophysiology of cardiovascular dis­ eases is more critical now than ever before because modern advances in basic and clinical sciences have prolonged the average life expectancy. Using a wide range of molecular and electrophysiological techniques, major advances are occurring frequently in the field of cardiovascular physiology and pharmacology. Such multifaceted approaches are preferred because human cardiovascular diseases are complex, requiring multiple interventions and an in-depth understanding of molecular mechanisms underlying the disease. The first section of this book focuses on molecular mechanisms of ion channel regulation. Eight of ten chapters in this section are devoted to the recent advances in molecular characterization and regulation of various types of potassium channels in cardiac, vascular, and neuronal tissues. A discussion of the structure and function of sodium and calcium channels is also included.

Keywords

cardiac myocytes cardiovascular cardiovascular regulation ion channels molecular mechanisms pathophysiology physiology regulation vascular smooth muscle cells

Editors and affiliations

  • Masao Endoh
    • 1
  • Martin Morad
    • 2
  • Hasso Scholz
    • 3
  • Toshihiko Iijima
    • 4
  1. 1.Department of PharmacologyYamagata University School of MedicineYamagataJapan
  2. 2.Georgetown University Medical CenterUSA
  3. 3.Pharmakologisches InstitutUniversitäts-Krankenhaus EppendorfHamburgGermany
  4. 4.Department of PharmacologyAkita University School of MedicineAkita 010Japan

Bibliographic information