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Molecular Pathology of Gastroenterological Cancer

Application to Clinical Practice

  • Eiichi Tahara

Table of contents

  1. Front Matter
    Pages II-VIII
  2. Hiroko Ohgaki, Takashi Sugimura
    Pages 1-14
  3. Yusuke Nakamura, Takashi Tokino, Minoru Isomura, Johji Inazawa, Takahisa Aoki, Takahiro Mori et al.
    Pages 15-21
  4. Pelayo Correa, Mark Miller, Elizabeth E. Mannick
    Pages 23-29
  5. Kazuhiro Yoshida, Wataru Yasui, Yoshihiro Kagawa, Eiichi Tahara
    Pages 31-41
  6. Atsushi Ochiai, Setsuo Hirohashi
    Pages 43-53
  7. Hiroshi Yokozaki, Hiroki Kuniyasu, Shuho Semba, Wataru Yasui, Eiichi Tahara
    Pages 55-70
  8. Hisao Ito, Masato Ishida, Satoshi Ohfuji, Mitsuhiko Osaki, Hisae Hayashi, Shigeru Tatebe
    Pages 81-92
  9. Fumio Shimamoto, Shinji Tanaka, Eiichi Tahara
    Pages 93-106
  10. Kiyomi Taniyama, Naomi Sasaki, Hiroshi Maruyama, Hayao Nakai, Hirofumi Nakatsuka, Kazushige Toyama et al.
    Pages 107-127
  11. Wataru Yasui, Hiroshi Yokozaki, Eiichi Tahara
    Pages 187-207
  12. Libin Jia, Xin Wei Wang, Zongtang Sun, Curtis C. Harris
    Pages 209-218
  13. Christopher J. Bakkenist, James O’D. McGee
    Pages 219-243
  14. Hidetoshi Tahara, Eiji Tahara, Eiichi Tahara, Toshinori Ide
    Pages 245-259
  15. Back Matter
    Pages 261-267

About this book

Introduction

Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas­ ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo­ rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop­ me nt and progression of esophageal, gastric, and colon cancer require mul­ tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi­ tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi­ cal Association Clinical Laboratory since August 1993.

Keywords

apoptosis cancer carcinogenesis carcinoma colon colorectal cancer gastric cancer gastroenterology gastrointestinal cancer genetics metastasis molecular genetics molecular pathology pathology stomach

Editors and affiliations

  • Eiichi Tahara
    • 1
  1. 1.Faculty of Medicine, First Department of PathologyHiroshima University School of MedicineMinami-ku, Hiroshima 734Japan

Bibliographic information