Major Histocompatibility Complex

Evolution, Structure, and Function

  • Masanori Kasahara
Conference proceedings

Table of contents

  1. Front Matter
    Pages ii-xxiii
  2. Origin of the MHC

    1. Front Matter
      Pages 1-1
    2. Jan Klein, Akie Sato, Werner E. Mayer
      Pages 3-26
    3. Masanori Kasahara, Makoto Yawata, Takashi Suzuki
      Pages 27-44
    4. Jonathan P. Rast, Paola Oliveri, Eric H. Davidson
      Pages 66-74
  3. Genome organization of the MHC

    1. Front Matter
      Pages 75-75
    2. Eberhard Günther, Sofia Ioannidu, Lutz Walter
      Pages 77-90
    3. Kiyoshi Naruse, Akihiro Shima, Masaru Nonaka
      Pages 91-109
    4. Andreas Ziegler, Anke Ehlers, Simon Forbes, John Trowsdale, Barbara Uchanska-Ziegler, Armin Volz et al.
      Pages 110-130
    5. Shigehiko Kanaya, Tatsuo Fukagawa, Asako Ando, Hidetoshi Inoko, Yoshihiro Kudo, Toshimichi Ikemura
      Pages 131-145
    6. Roger Dawkins, Jemma Berry, Patricia Martinez, Silvana Gaudieri, Jennie Hui, Sonia Cattley et al.
      Pages 146-157
    7. Jerzy K. Kulski, Silvana Gaudieri, Roger L. Dawkins
      Pages 158-177
    8. Yoko Satta, Naoyuki Takahata
      Pages 178-185
    9. Silvana Gaudieri, Roger L. Dawkins, Kaori Habara, Jerzy K. Kulski, Takashi Gojobori
      Pages 186-200
  4. Function and evolutionary dynamics of MHC genes

    1. Front Matter
      Pages 201-201
    2. Keiji Tanaka, Nobuyuki Tanahashi, Naoki Shimbara
      Pages 203-212
    3. Lutz Walter, Jung Won Seo, Eberhard Günther
      Pages 213-221
    4. Akihiro Matsuura, Miyuki Kinebuchi
      Pages 222-235
    5. Marielle Afanassieff, Ronald M. Goto, Jennifer Ha, Rima Zoorob, Charles Auffray, Françoise Coudert et al.
      Pages 236-247
    6. Martin F. Flajnik, Yuko Ohta
      Pages 248-259
    7. Ulla B. Godwin, Michael Flores, Thomas J. McConnell, Melanie R. Wilson, Sylvie Quiniou, Norman W. Miller et al.
      Pages 260-272
    8. Shirley A. Ellis, Edward C. Holmes, Karen A. Staines, W. Ivan Morrison
      Pages 273-278
    9. Keith T. Ballingall, Anthony Luyai, Bernard Marasa, Declan J. McKeever
      Pages 279-284
  5. Natural killer gene complex

    1. Front Matter
      Pages 285-285
    2. Michael G. Brown, Anthony A. Scalzo, Wayne M. Yokoyama
      Pages 287-301
  6. MHC-pathogen coevolution

    1. Front Matter
      Pages 303-303
    2. Dagmar Bauer, Frank Momburg, Hartmut Hengel
      Pages 305-319
    3. Carol M. Kiekhaefer, David T. Evans, David H. O’Connor, David I. Watkins
      Pages 320-326
  7. MHC polymorphism

    1. Front Matter
      Pages 327-327
    2. Tomas F. Bergström, Steven J. Mack, Ulf Gyllensten, Henry A. Erlich
      Pages 329-346
    3. Karin Kriener, Colm O’hUigin, Jan Klein
      Pages 354-376
    4. Katsuko Hashiba, Shigeki Mitsunaga, Katsushi Tokunaga, Yoko Satta
      Pages 386-397
    5. Ann B. Begovich, William Klitz, Lori L. Steiner, Sarah Grams, Vina Suraj-Baker, Jill Hollenbach et al.
      Pages 412-426
    6. Steven J. Mack, Teodorica L. Bugawan, Mark Stoneking, Muhammad Saha, Hans-Peter Beck, Henry A. Erlich
      Pages 427-445
    7. Xiaojiang Gao, Sue Lester, Anthony Veale, Barry Boettcher, Bart Currie, James McCluskey et al.
      Pages 446-462
    8. Pablo Morales, Jorge Martinez-Laso, Maria Jose Castro, Eduardo Gomez-Casado, Miguel Alvarez, Ricardo Rojo et al.
      Pages 463-479
    9. Miki Komatsu-Wakui, Jun Ohashi, Katsushi Tokunaga, Yoshihide Ishikawa, Kouichi Kashiwase, Hitoshi Ando et al.
      Pages 480-486
    10. Keiko Udaka, Karl-Heinz Wiesmüller, Günther Jung
      Pages 487-502
    11. Jan Böhme, Kari Högstrand
      Pages 503-517
    12. Akie Sato, Felipe Figueroa, Werner E. Mayer, Peter R. Grant, B. Rosemary Grant, Jan Klein
      Pages 518-541
  8. Back Matter
    Pages 555-561

About these proceedings


Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter­ est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna­ tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi­ zation of the MHC in humans and other model vertebrates, MHC-parasite co­ evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen­ eral.


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Editors and affiliations

  • Masanori Kasahara
    • 1
    • 2
  1. 1.Department of Biosystems Science, School of Advanced SciencesThe Graduate University for Advanced StudiesHayamaJapan
  2. 2.CRESTJapan Science and Technology CorporationHayamaJapan

Bibliographic information