D-Amino Acids

Physiology, Metabolism, and Application

  • Tohru Yoshimura
  • Toru Nishikawa
  • Hiroshi Homma

Table of contents

  1. Front Matter
    Pages i-ix
  2. Detection of d-Amino Acids

    1. Front Matter
      Pages 1-1
    2. Yurika Miyoshi, Reiko Koga, Kenji Hamase
      Pages 3-17
  3. Physiological Functions and Pathophysiology of d-Serine

    1. Front Matter
      Pages 19-19
    2. Toru Nishikawa
      Pages 21-25
    3. Jean-Pierre Mothet, Grégoire Mondielli, Magalie Martineau
      Pages 27-50
    4. Hiroaki Sakaue, Hiroko Ohide, Masahiro Yamanaka, Ryuichi Konno
      Pages 51-64
    5. Toru Nishikawa
      Pages 81-99
    6. Jumpei Sasabe, Sadakazu Aiso
      Pages 137-149
  4. Function of d-Aspartate

    1. Front Matter
      Pages 151-151
    2. Hiroshi Homma
      Pages 153-156
    3. Maria Maddalena Di Fiore, Lavinia Burrone, Alessandra Santillo, Gabriella Chieffi Baccari
      Pages 157-172
    4. Amit V. Patel, Takayuki Kawai, Stanislav S. Rubakhin, Jonathan V. Sweedler
      Pages 173-197
    5. Hiroshi Homma, Masumi Katane
      Pages 199-218
    6. Francesco Errico, Alessandro Usiello
      Pages 219-237
  5. d-Amino Acid Residues in Proteins

    1. Front Matter
      Pages 239-239
    2. Noriko Fujii, Takumi Takata, Norihiko Fujii, Kenzo Aki, Hiroaki Sakaue
      Pages 241-254
  6. d-Amino Acid Metabolizing Enzyme

    1. Front Matter
      Pages 255-255
    2. Tohru Yoshimura
      Pages 257-268
    3. Naoko Yoshikawa, Mohammed Golam Sarower, Hiroki Abe
      Pages 269-282
    4. Darrick T. Balu
      Pages 283-291
    5. Yusuke Kato, Diem Hong Tran, Huong Thi Thanh Trinh, Kiyoshi Fukui
      Pages 293-309
    6. Tomokazu Ito, Tohru Yoshimura, Tetsuo Ishida, Hiroyuki Tanaka
      Pages 311-322
  7. d-Amino Acids in Foods

    1. Front Matter
      Pages 339-339
    2. Yuta Mutaguchi, Jyunpei Kobayashi, Tadao Oikawa, Toshihisa Ohshima
      Pages 341-357

About this book


This book presents a comprehensive overview of the roles of ᴅ-amino acids and latest research findings, to reveal their fascinating aspects and to facilitate better understanding of their important roles in physiology and diseases. It also provides useful hints for the development of drugs and functional foods. ᴅ-Amino acids were once called unnatural amino acids and were considered to be insignificant for eukaryotes especially in mammals. However, different ᴅ-amino acids have been revealed to be distributed in various mammalian tissues and to bear important physiological roles. For example, ᴅ-serine is implicated in memory formation and learning, and its abnormal concentration in tissues have been reported in neurological diseases such as schizophrenia and amyotrophic lateral sclerosis. ᴅ-Aspartate is found in a variety of mammalian tissues, particularly in the central nervous system and the genitals. ᴅ-Aspartate facilitates the endocrine secretion of prolactin, inhibits the secretion of melatonin, and plays a peculiar role in the control of reproductive functions in mammals, including the stimulation of testosterone synthesis. Written by the leading scientists in the field, this book is a valuable source of information for researchers in biochemistry, physiology, and neuroscience, as well as in the pharmaceutical and food industries.


D-Serine D-Aspartate Brain function Schizophrenia Amyotrophic lateral sclerosis (ALS) N-methyl-D-aspartate receptor D-Amino acid oxidase Serine racemase D-Serine dehydratase

Editors and affiliations

  • Tohru Yoshimura
    • 1
  • Toru Nishikawa
    • 2
  • Hiroshi Homma
    • 3
  1. 1.Department of Applied Molecular Biosciences Graduate School of Bioagricultural SciencesNagoya UniversityNagoyaJapan
  2. 2.Department of Psychiatry and Behavioral Sciences Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan
  3. 3.Laboratory of Biomolecular Science Department of Pharmaceutical Life SciencesKitasato UniversityTokyoJapan

Bibliographic information