Chronic Inflammation

Mechanisms and Regulation

  • Masayuki Miyasaka
  • Kiyoshi Takatsu

Table of contents

  1. Front Matter
    Pages i-xi
  2. Basic Mechanisms Underlying Induction, Progression, and Resolution of Chronic Inflammation

    1. Front Matter
      Pages 1-1
    2. Tomohiro Aoki, Shuh Narumiya
      Pages 3-17
    3. Tatsuya Tsukui, Shigeyuki Shichino, Takeshi Shimaoka, Satoshi Ueha, Kouji Matsushima
      Pages 19-36
    4. Daisuke Ito, Atsushi Kumanogoh
      Pages 37-48
    5. Y. Ito, S. Mokuda, K. Miyata, T. Matsushima, H. Asahara
      Pages 49-61
    6. Takayuki Kuraishi, Hirotaka Kanoh, Yoshiki Momiuchi, Hiroyuki Kenmoku, Shoichiro Kurata
      Pages 119-129
  3. Imaging Analyses of Chronic Inflammation

    1. Front Matter
      Pages 131-131
    2. Junichi Kikuta, Keizo Nishikawa, Masaru Ishii
      Pages 133-145
  4. Chronic Inflammation and Cancer

  5. Chronic Inflammation and Obesity/Environmental Stress

    1. Front Matter
      Pages 247-247
    2. Takayoshi Suganami, Miyako Tanaka, Yoshihiro Ogawa
      Pages 291-298
    3. Kohsuke Takeda, Daichi Sadatomi, Susumu Tanimura
      Pages 299-308
  6. Chronic Inflammation and Innate Immunity

  7. Chronic Inflammation and Adaptive Immunity

    1. Front Matter
      Pages 399-399
    2. Yusuke Endo, Kiyoshi Hirahara, Kenta Shinoda, Tomohisa Iinuma, Heizaburo Yamamoto, Shinichiro Motohashi et al.
      Pages 401-415
    3. Masakatsu Yamashita, Makoto Kuwahara, Junpei Suzuki, Takeshi Yamada
      Pages 417-427
    4. Mohamed El Sherif Gadelhaq Badr, Kikumi Hata, Masae Furuhata, Hiroko Toyota, Tadashi Yokosuka
      Pages 441-457
    5. Masayuki Miyasaka, Akira Takeda, Erina Hata, Naoko Sasaki, Eiji Umemoto, Sirpa Jalkanen
      Pages 459-471
  8. Chronic Inflammation and Autoimmune Diseases

  9. Chronic Inflammation and Ageing

    1. Front Matter
      Pages 539-539
    2. Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro
      Pages 541-553

About this book


This book provides readers with the most up-to-date information on cutting-edge research concerning chronic inflammation. We now know that when inflammation becomes chronic, it acts as a strong disease-promoting factor in a variety of disorders including arteriosclerosis, obesity, cancer, and Alzheimer disease. Chronic inflammation is hence called as the “silent killer”; it upsets the body’s homeostatic mechanism insidiously. In spite of these developments, we know very little about the mechanism underlying chronic inflammation. Particularly, we do not know precisely what induces chronic inflammation or what promotes its prolongation in a spatiotemporal framework. Neither do we have clear knowledge about how chronic inflammation destroys various tissues or how it predisposes individuals to many different diseases. To make the situation worse, we have no effective treatment against chronic inflammation. 

Since 2010, two major research programs (CREST and PRESTO) aimed at clarifying the mechanisms underlying chronic inflammation were launched in Japan, and investigators of different research areas with a brilliant track record were selected by their research proposals. Subsequently they have made their best efforts to answer the conundrum concerning chronic inflammation. This book is a compendium of such research efforts. In each chapter, the CREST- or PRESTO-funded researchers summarize their original work concerning mechanisms of induction, progression, or resolution underlying chronic inflammation. The most emphasized characteristic is the molecular aspect of chronic inflammation. The book thus presents the most recent progress made in the molecular understanding of chronic inflammation.


Chronic diseases Proinflammatory molecules Tissue remodeling Fibrosis Cytokines Chemokines Innate lymphoid cells

Editors and affiliations

  • Masayuki Miyasaka
    • 1
  • Kiyoshi Takatsu
    • 2
  1. 1.Interdisciplinary Program for Biomedical Sciences Institute for Academic InitiativesOsaka UniversitySuitaJapan
  2. 2.Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical SciencesUniversity of ToyamaToyamaJapan

Bibliographic information