Helicobacter pylori Research

From Bench to Bedside

  • Steffen Backert
  • Yoshio Yamaoka

Table of contents

  1. Front Matter
    Pages i-xi
  2. Bacteriology and Molecular Biology

    1. Front Matter
      Pages 1-1
    2. Judyta Praszkier, Philip Sutton, Richard L. Ferrero
      Pages 57-87
    3. Steffen Backert, Giuseppe Zanotti, Judith Lind, Carmen Isabell Asche, Nicole Tegtmeyer
      Pages 89-111
    4. Timothy L. Cover, Robin L. Holland, Steven R. Blanke
      Pages 113-141
    5. Sandy R. Pernitzsch, Fabien Darfeuille, Cynthia M. Sharma
      Pages 189-216
    6. Bram Flahou, Freddy Haesebrouck, Annemieke Smet
      Pages 233-269
  3. Immune Responses and Host Factors

    1. Front Matter
      Pages 271-271
    2. Jay V. Solnick, Kathryn A. Eaton, Richard M. Peek Jr.
      Pages 273-297
    3. Anne Müller, Mara L. Hartung
      Pages 299-323
    4. Hiroko Oshima, Mizuho Nakayama, Masanobu Oshima
      Pages 325-338
    5. Mairi H. McLean, Ruairidh Nicoll, Cheryl Saw, Georgina L. Hold, Emad M. El-Omar
      Pages 339-362
  4. Helicobacter pylori-Associated Diseases

    1. Front Matter
      Pages 363-363
    2. Doron Boltin, Yaron Niv
      Pages 365-385
    3. Robert M. Genta, Richard H. Lash
      Pages 387-402

About this book


This book provides the current updated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori is a class I carcinogen and one of the most common infections in the world. While most people colonized by H. pylori will remain asymptomatic, up to 20 % of them may develop serious gastroduodenal disease such as peptic ulcers or gastric cancer. H. pylori is the only known bacterium linked to the development of cancer and consequently is an important focus of research. Outstanding international experts from diverse scientific disciplines contribute here to give detailed insights into the current understanding concerning the physiology and role of this pathogen. Both basic science and clinical research with actual practical consequences are taken into account. The chapters target microbiology, epidemiology, genetics, biochemistry, interactions with the immune system, signal transduction, pathogenic mechanisms in the gastroduodenal mucosa, gastric disease development, and therapy including antibiotics or probiotics treatment as well as vaccination strategies. This book is an important reference not only for clinicians but also microbiologists. It provides in a single volume an up-to-date summary of our current knowledge of this microbe and the multiple ways in which it impacts upon public health in all parts of the world.


H. pylori Gastric cancer Pathogenesis Eradication therapy Co-evolution

Editors and affiliations

  • Steffen Backert
    • 1
  • Yoshio Yamaoka
    • 2
  1. 1.Division of Microbiology;Dept of BiologyFriedrich Alexander Univ;Erlangen-NurembErlangenGermany
  2. 2.Dept of Medicine-GastroenteologyBaylor College of MedicineHoustonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-4-431-55936-8
  • Copyright Information Springer Japan 2016
  • Publisher Name Springer, Tokyo
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-4-431-55934-4
  • Online ISBN 978-4-431-55936-8
  • About this book