Table of contents

  1. Front Matter
    Pages i-ix
  2. DNA Replication

    1. Front Matter
      Pages 1-1
    2. Hiroyuki Araki
      Pages 3-22
    3. James R. A. Hutchins, Antoine Aze, Philippe Coulombe, Marcel Méchali
      Pages 23-52
    4. Motoshi Hayano, Seiji Matsumoto, Hisao Masai
      Pages 53-69
  3. DNA Recombination

    1. Front Matter
      Pages 71-71
    2. Marek Sebesta, Lumir Krejci
      Pages 73-109
    3. Takatomi Yamada, Kunihiro Ohta
      Pages 111-129
    4. Drew Thacker, Scott Keeney
      Pages 131-151
  4. DNA Repair

    1. Front Matter
      Pages 153-153
    2. Masamichi Ishiai, Junya Tomida, Akiko Itaya, James Hejna, Minoru Takata
      Pages 175-210
    3. Gondichatnahalli M. Lingaraju, Kerstin Böhm, Julius Rabl, Simone Cavadini, Eric S. Fischer, Susanne A. Kassube et al.
      Pages 211-232
  5. Genome Instability and Mutagenesis

    1. Front Matter
      Pages 233-233
    2. Yuji Masuda, Fumio Hanaoka, Chikahide Masutani
      Pages 249-304
    3. Richard Fishel, Jong-Bong Lee
      Pages 305-339
    4. Dik C. van Gent, Hanna IJspeert, Mirjam van der Burg
      Pages 341-362
  6. Chromosome Dynamics and Functions

    1. Front Matter
      Pages 363-363

About this book

Introduction

This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

Keywords

DNA replication DNA recombination DNA repair Genome integrity Chromosome Epigenetic information Molecular pathology Cell cycle checkpoint Somatic hypermutation

Editors and affiliations

  • Fumio Hanaoka
    • 1
  • Kaoru Sugasawa
    • 2
  1. 1.Dept of Life Sci, Faculty of Sci.Gakushuin UniversityToshima, TokyoJapan
  2. 2.Biosignal Research CenterKobe UniversityKobeJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-4-431-55873-6
  • Copyright Information Springer Japan 2016
  • Publisher Name Springer, Tokyo
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-4-431-55871-2
  • Online ISBN 978-4-431-55873-6
  • About this book