© 2015


Multiple Functional Modifiers and Targets for New Drug Discovery

  • Kiyotaka Hitomi
  • Soichi Kojima
  • Laszlo Fesus

Table of contents

  1. Front Matter
    Pages i-viii
  2. Máté Á. Demény, Ilma Korponay-Szabó, László Fésüs
    Pages 1-41
  3. Yutaka Furutani, Soichi Kojima
    Pages 43-62
  4. Kiyotaka Hitomi, Hideki Tatsukawa
    Pages 63-82
  5. Toshio Shibata, Shun-ichiro Kawabata
    Pages 117-127
  6. Soo-Youl Kim
    Pages 153-170
  7. Manuela D’Eletto, Federica Rossin, Maria Grazia Farrace, Mauro Piacentini
    Pages 171-191
  8. Rasmus Iversen, Ludvig M. Sollid
    Pages 193-214
  9. Elisabetta A. M. Verderio, Giulia Furini, Izhar W. Burhan, Timothy S. Johnson
    Pages 229-262
  10. Julianne Feola, Alina Monteagudo, Laura Yunes-Medina, Gail V. W. Johnson
    Pages 283-314
  11. Eui Man Jeong, In-Gyu Kim
    Pages 315-331
  12. Moyuru Hayashi, Kohji Kasahara
    Pages 333-346
  13. Jeffrey W. Keillor
    Pages 347-372
  14. Back Matter
    Pages 385-391

About this book


This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenotypes, the publication of the present transglutaminase book was planned, to consist of review articles by 17 expert investigators working in this exciting area of research. The book contains detailed information related to several transglutaminases from aspects in chemical and cellular biology, medical sciences, and biotechnology that will also supply starting points for drug discovery. Although many prominent findings have been published in recent years, this type of comprehensive review book has been missing in the scientific literature. This volume will be useful for investigators who either currently work on or will start addressing transglutaminase-related research, and beyond that, for a broad audience in the scientific community. 


Subcellular localization Substrates and inhibitors Transglutaminase KO mice Celiac disease Neurological diseases Metastasis Bone and matrix Oxidative stress Drug discovery

Editors and affiliations

  • Kiyotaka Hitomi
    • 1
  • Soichi Kojima
    • 2
  • Laszlo Fesus
    • 3
  1. 1.Grad Sch of Pharmaceutical SciencesNagoya UniversityNagoyaJapan
  2. 2.Micro-Signaling Regulation Technol. UnitRIKEN Center for Life Sci. TechnologiesWako, SaitamaJapan
  3. 3.Dept. Biochemistry and Molecular BiologyUniversity of DebrecenDebrecenHungary

Bibliographic information