Aging Mechanisms

Longevity, Metabolism, and Brain Aging

  • Nozomu Mori
  • Inhee Mook-Jung

Table of contents

  1. Front Matter
    Pages i-xiv
  2. From Hypotheses to Mechanisms

  3. Human Longevity: Centenarianism and Progeria

    1. Front Matter
      Pages 29-29
    2. Yasumichi Arai, Michiyo Takayama, Hiroki Inagaki, Yasuyuki Gondo, Yukie Masui, Nobuyoshi Hirose
      Pages 31-49
    3. Fanbiao Meng, Baohua Liu, Zhongjun Zhou
      Pages 51-63
  4. Stem Cells, Cultured Neurons, and Lower Animal Models

    1. Front Matter
      Pages 65-65
    2. Naoaki Ishii, Takamasa Ishii, Philip S. Hartman
      Pages 111-122
    3. Yujin Lee, Seon Woo A. An, Murat Artan, Mihwa Seo, Ara B. Hwang, Dae-Eun Jeong et al.
      Pages 123-169
    4. Dong Kyu Kim, Seung-Jae Lee
      Pages 171-180
  5. Metabolism: Factors Affecting Tissue Aging

    1. Front Matter
      Pages 181-181
    2. Yo-ichi Nabeshima
      Pages 183-198
    3. Ryoichi Mori, Seongjoon Park, Isao Shimokawa
      Pages 199-208
    4. Kotaro Azuma, Satoshi Inoue
      Pages 223-239
  6. Aging Brain: Adult Neurogenesis, Synaptic Plasticity, and Brain Volume

  7. Aged Brain: Mechanisms of Neurodegeneration

    1. Front Matter
      Pages 303-303
    2. Toshiharu Suzuki, Ayano Kimura, Kyoko Chiba, Tadashi Nakaya, Saori Hata
      Pages 305-318
    3. Shoko Hashimoto, Per Nilsson, Takaomi C. Saido
      Pages 319-339
    4. Sun-Ho Han, Jong-Chan Park, Inhee Mook-Jung
      Pages 341-354
  8. Anti-brain Aging: Neuroprotection and Therapeutic Approaches

  9. Back Matter
    Pages 431-439

About this book


This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong. Starting with a comprehensive overview of various hypotheses on biological mechanisms of aging by Dr. Sataro Goto, each chapter covers broad aspects of the most recent findings in aging-related topics: centenarian studies and genome analysis of progeria, metabolic biochemistry and neurobiology, longevity controls in yeast and nematodes, oxidative stress and calorie restriction, and neurodegeneration mechanisms in Alzheimer’s and Huntington’s diseases, with further potential therapeutic approaches to these age-related neurodegenerative diseases. Also included, in part, is a summary and the outcomes of a scientific discussion forum called the Asian Aging Core for Longevity (AACL) that has been held annually alternating between Japan and Korea during the last decade. This book can serve as a useful resource for finding appropriate collaborators in the areas it covers. The target readership is made up of graduate students and researchers at universities, medical and/or life-science schools, and biomedical and pharmaceutical institutes.

Why does aging exist? How do we age? How is each organism’s lifespan determined? These are fundamental questions in the field. We may be still far from achieving a complete view of aging mechanisms, but this book, Aging Mechanisms, offers an excellent opportunity to become familiar with the most updated progress in the biomedical research of aging in Japan and Korea, the two leading nations for human longevity.


Aging Brain Longevity Metabolism Neurodegeneration

Editors and affiliations

  • Nozomu Mori
    • 1
  • Inhee Mook-Jung
    • 2
  1. 1.Department of Anatomy and NeurobiologyNagasaki University School of MedicineNagasakiJapan
  2. 2.Department of Biomedical SciencesSeoul National University College of MedicineSeoulKorea (Republic of)

Bibliographic information