Musculoskeletal Disease Associated with Diabetes Mellitus

  • Masaaki┬áInaba

Table of contents

  1. Front Matter
    Pages i-viii
  2. Bone Diseases

  3. Muscle Diseases

    1. Front Matter
      Pages 125-125
    2. Nobuharu L. Fujii
      Pages 127-137
    3. Katsuhito Mori, Tomoaki Morioka, Koka Motoyama, Masanori Emoto
      Pages 171-183
    4. Toshinari Takamura, Hirofumi Misu, Shuichi Kaneko
      Pages 185-199
    5. Masanori Emoto, Tomoaki Morioka, Hisayo Yokoyama, Yuko Sawada-Yamazaki, Koka Motoyama, Katsuhito Mori et al.
      Pages 215-235
    6. Ken Sugimoto, Chung-Chi Wang, Hiromi Rakugi
      Pages 237-252
    7. Masayuki Hosoi, Yosuke Yakushiji, Shiro Tanaka
      Pages 269-277

About this book


The aim of this book is to review the latest findings on musculoskeletal disease associated with diabetes. It has been increasingly recognized that maintaining skeletal health is an important factor in achieving longevity in healthy subjects. Diabetes has been established as a disease independently associated with sarcopenia and increased risk of bone fracture resulting from osteoporosis; therefore, it is reasonable to maintain that musculoskeletal health is important in preserving good health. As either bone or muscle is intimately involved in the regulation of metabolic status, keeping the musculoskeletal system healthy is important for improving abnormal glucose metabolism toward normal levels and is vital, as well, for maintaining normal activities of daily living. Muscle is a target of insulin for enhancing the entry of glucose; thus it is conceivable that sarcopenia and muscle containing fat streaks causes insulin resistance in diabetic patients. Furthermore, bone is an organ that regulates Ca and Pi levels in serum by releasing or resorbing Ca and Pi to and from bone tissue. It is now known that bone is a definitive endocrine organ for regulating glucose metabolism and Pi metabolism by secreting osteocalcin and FGF-23 from osteocytes/osteoblasts. Readers will learn of the recent findings in this area, and this book will benefit physicians who deal with diabetes, particularly orthopedists and bone specialists, as well as all physical therapists.


bone metabolism glucose metabolism insulin osteoporosis sarcopenia

Editors and affiliations

  • Masaaki┬áInaba
    • 1
  1. 1.Graduate School of MedicineOsaka City UniversityOsakaJapan

Bibliographic information