Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia

  • Masahiro Kizaki

Table of contents

  1. Front Matter
    Pages i-viii
  2. Hiromi Iwasaki, Koichi Akashi
    Pages 1-10
  3. Atsushi Hirao, Yuko Tadokoro, Masaya Ueno
    Pages 11-28
  4. Jerald Radich, Daniel Egan
    Pages 53-67
  5. David T. Yeung, Susan Branford
    Pages 101-129
  6. Alessandro Morotti, Carmen Fava, Giuseppe Saglio
    Pages 131-145
  7. Franck E. Nicolini, Marie Balsat, Hélène Labussière-Wallet, Mohamad Sobh, Arthur Bert, Maël Heiblig
    Pages 147-159
  8. Gianantonio Rosti, Fausto Castagnetti, Gabriele Gugliotta, Michele Baccarani
    Pages 161-166
  9. David M. Ross, Timothy P. Hughes
    Pages 183-193

About this book


Molecular Pathogenesis and Treatment of Chronic Myelogenous Leukemia provides a comprehensive understanding of the recent molecular genetics of Chronic Myelogenous Leukemia (CML) and a characterization of the molecular targets for drug development. Included are therapeutic implications, diagnosis, and prognosis for understanding and facilitating daily practice in the management of patients with CML.

Understanding of the pathogenesis and therapy of hematological malignancies such as CML has grown significantly in recent years. This development owe much to the progress in molecular biology and now makes a major contribution to diagnosis and to treatment that pharmacologically targets the molecular events of CML. Molecular targeting therapy with newly developed agents such as small molecules and antibodies for hematological malignancies are being discovered after years of research. Some of these, including tyrosine kinase inhibitors such as imatinib, nilotinib, and dasatinib, lead to increased survival rates and improved therapies. With the opinion leaders of basic and clinical research in the field as authors, this book reviews recent advances in the biology of CML.


Chronic Myeloid Leukemia Molecular-targeting thrapy Stem Cell TKI Tyrosine Kinase Inhibitor molecular gnetics

Editors and affiliations

  • Masahiro Kizaki
    • 1
  1. 1.Department of HematologySaitama Medical Center Saitama MEdical UniversityKawagoeJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Japan 2016
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-55713-5
  • Online ISBN 978-4-431-55714-2
  • Buy this book on publisher's site