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© 2015

Long Noncoding RNAs

Structures and Functions

  • Riki Kurokawa
Book

Table of contents

  1. Front Matter
    Pages i-viii
  2. Bioinformatics and Other Methodologies for lncRNAs

    1. Front Matter
      Pages 1-1
    2. Ganesh N. Pandian, Junetha Syed, Hiroshi Sugiyama
      Pages 23-43
  3. Atomic and Molecular Structures of lncRNAs

  4. Molecular Functions of lncRNAs

  5. Biological Actions of lncRNAs

    1. Front Matter
      Pages 131-131
    2. Yuko Hasegawa, Shinichi Nakagawa
      Pages 133-149
  6. Potential Outcomes for Clinical Medicine

  7. Back Matter
    Pages 251-257

About this book

Introduction

This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular, and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests.

Keywords

Bioinformatics Chemical biology Epigenetics Macrophage RNA medicine Steroid hormone Transcription X-chromosome inactivation lncRNA

Editors and affiliations

  • Riki Kurokawa
    • 1
  1. 1.Division of Gene Structure and Function, Research Center for Genomic MedicineSaitama Medical UniversitySaitamaJapan

Bibliographic information

Reviews

“The book ‘Long Noncoding RNAs Structures and Functions’ introduces long noncoding RNAs (lncRNAs) and outlines molecular mechanisms of their activity and potential biological function, mostly associated with transcriptional or epigenetic regulation. … This book reflects needs of understanding of lncRNAs function and provides a valuable summary of available information.” (Dana Jurkovicova, Neoplasma, Vol. 63 (2), 2016)