Personalized Treatment of Breast Cancer

  • Masakazu Toi
  • Eric Winer
  • John Benson
  • Suzanne Klimberg

Table of contents

  1. Front Matter
    Pages i-ix
  2. Treatment for the Patients Having Breast Cancer High-Risk

    1. Front Matter
      Pages 1-1
    2. Eun-Kyu Kim, Sung-Won Kim, Dong-Young Noh
      Pages 3-20
    3. Mihir M. Shah, Holly J. Pederson, Risal Djohan, Joseph P. Crowe, Stephen R. Grobmyer
      Pages 21-32
  3. Axillary Treatment

  4. Radiation Therapy

    1. Front Matter
      Pages 129-129
    2. Ian H. Kunkler, Carol Ward, Corey Speers, Lori Pierce, Felix Feng, James Meehan et al.
      Pages 131-149
    3. Michio Yoshimura, Chikako Yamauchi
      Pages 151-169
  5. Preoperative Hormone Therapy

    1. Front Matter
      Pages 187-187
    2. Yukiko Shibahara, Hironobu Sasano
      Pages 217-231
  6. Preoperative Chemotherapy

    1. Front Matter
      Pages 233-233
    2. Jenny Furlanetto, Gunter von Minckwitz
      Pages 235-246
    3. Hiroko Masuda, Norikazu Masuda
      Pages 247-261
    4. John Mathew, Carol-Ann Courtney, Kelly K. Hunt, John F. Robertson
      Pages 263-293
    5. Shotaro Kanao, Masako Kataoka
      Pages 295-308
  7. Preoperative Anti-HER2 Therapy

    1. Front Matter
      Pages 309-309
    2. Stephen R. Grobmyer, Stephanie A. Valente, Sheen Cherian, Holly J. Pederson, Jame Abraham
      Pages 323-331
  8. Mathematical Prediction/Assessment Model

    1. Front Matter
      Pages 333-333
    2. José Luiz B. Bevilacqua, Paulo R. de Alcantara Filho, Lillian Fraianella, Carla Curi
      Pages 347-380
    3. Masahiro Sugimoto, Masahiro Takada
      Pages 381-388

About this book


This book deals with the essential factors in the personalization of treatment for primary breast cancer. These include host issues, lymph node surgery, radiation therapy, and preoperative systemic treatment requiring specialized knowledge, multidisciplinary care experience, techniques, and research. Locoregional treatment in conjunction with systemic treatments is another important factor, with options for local therapy significantly affected by genetic BRCA mutation. Axillary treatment issues have become top priorities in recent primary breast cancer care, and these are highlighted in the book’s presentation of technological advances in lymph node mapping and diagnosis, axillary clearance in patients with nodal metastasis, and the role of axillary surgery. Attention is also given to locoregional treatment after preoperative systemic therapy. Because therapeutic impact differs depending upon biological characteristics such as tumor subtype, local therapy should be based both on tumor biology and on therapeutic response in parallel. Associated translational research and mathematical prediction tools such as nomograms also are introduced. This book provides the essence of primary breast cancer care, particularly its individualization with novel therapeutic concepts and strategies, and will greatly benefit physicians and clinical investigators in breast cancer institutions.


BRCA axillary treatment lymph node surgery preoperative systemic treatment radiation therapy

Editors and affiliations

  • Masakazu Toi
    • 1
  • Eric Winer
    • 2
  • John Benson
    • 3
  • Suzanne Klimberg
    • 4
  1. 1.Department of Breast Surgery Graduate ScKyoto UniversityKyotoJapan
  2. 2.Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  3. 3.Addenbrooke’s HospitalCambridge University HospitalsCambridgeUnited Kingdom
  4. 4.University of Arkansas for Medical ScienLittle RockUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Japan 2016
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-55551-3
  • Online ISBN 978-4-431-55552-0
  • Buy this book on publisher's site