Presynaptic Terminals

  • Sumiko Mochida

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Overview

  3. Presynaptic Active Zone Proteins

    1. Front Matter
      Pages 45-45
    2. Thomas Dresbach
      Pages 47-68
  4. Synaptic Vesicle Fusion

    1. Front Matter
      Pages 85-85
    2. Ira Milosevic, Jakob B. Sørensen
      Pages 87-127
    3. Yasunori Yamamoto, Toshiaki Sakisaka
      Pages 129-140
    4. Hiroshi Tokumaru
      Pages 141-147
    5. Tei-ichi Nishiki, Kentaro Kuroki, Toshio Masumoto, Hideki Matsui
      Pages 167-194
    6. Karina Leal, Sumiko Mochida
      Pages 195-220
  5. Synaptic Vesicle Endocytosis

    1. Front Matter
      Pages 221-221
    2. Ira Milosevic
      Pages 223-256
    3. Shota Tanifuji, Sumiko Mochida
      Pages 257-271
  6. Synaptic Vesicle Refilling and Storage

    1. Front Matter
      Pages 273-273
    2. Fabrizia C. Guarnieri, Fabio Benfenati, Flavia Valtorta
      Pages 295-326
  7. Synaptic Vesicle Pools

    1. Front Matter
      Pages 327-327
    2. Sven Truckenbrodt, Silvio O. Rizzoli
      Pages 329-359
  8. Back Matter
    Pages 361-365

About this book


This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase. These include proteins that control the final step of neurotransmitter release, in response to a neural signal, and the first step of vesicle endocytosis, which helps maintain stable neurotransmitter release in response to unceasing neural signals arriving at presynaptic terminals.

Neural networks transmit input and output signals of action potentials using chemical synapses. The strength of the signal from one to another neuron can be tuned by the neural signal itself as it induces Ca2+ entry and by other neurons’ signals that modify Ca2+ entry through voltage-gated Ca2+ channels at the active zone, where chemical neurotransmitters are released from synaptic vesicles via exocytosis. Synaptic vesicles are docked and primed at the active zone prior to exocytosis and are endocytosed after exocytosis for reuse at a small presynaptic terminal. Recycled vesicles are refilled with transmitters and stored for a future round of exocytosis. Thus, synaptic vesicles in presynaptic terminals go through various phases. Each vesicle phase is well orchestrated by numerous proteins and advance step-by-step with neural activities.

The fine regulations of synaptic vesicle phases by numerous proteins is an exciting subject, and systematic, well-organized explanations in this book will help the reader easily learn about complicated molecular mechanisms in presynaptic terminals.


Active zone Endocytosis Exocytosis Presynaptic terminal Synaptic proteins Synaptic vesicles

Editors and affiliations

  • Sumiko Mochida
    • 1
  1. 1.Department of PhysiologyTokyo Medical UniversityTokyoJapan

Bibliographic information