New Principles in Developmental Processes

  • Hisato Kondoh
  • Atsushi Kuroiwa

Table of contents

  1. Front Matter
    Pages i-ix
  2. Making Cells Unequal in a Tissue to Form Embryos and Organs

  3. Choosing a Fate from Multiple Potencies

  4. Cells in a Community of Reorganizing Tissues

  5. Heterologous Tissue Interactions to Generate a Function

  6. New Players in Signaling Systems

  7. Evolutional Variations Stemming from Common Principles

    1. Front Matter
      Pages 263-263
    2. Tohru Yano, Haruka Matsubara, Shiro Egawa, Koun Onodera, Koji Tamura
      Pages 291-302
    3. Naoki Irie, Hiroshi Nagashima, Shigeru Kuratani
      Pages 303-314
  8. Back Matter
    Pages 315-321

About this book


This book highlights representatives of emerging new principles in the developmental biology field, such as cell competition, tissue asymmetry, a farewell to classical germ layer theory, and various new insights into tissue morphogenesis and specification based on the most modern experimental approaches. A large-scale paradigm shift occurred in the last decade owing to innovations in powerful live imaging technologies, gene manipulation techniques in developing embryos, and in-depth understanding of signaling systems, among other advances. Comparison between different animal species also highlighted commonalities of underlying principles, which had not been previously recognized. This book represents important elements that caused that paradigm shift, showing typical examples of phenomena or experimental evidence. It has as its mission the highlighting of important problems that currently are being solved, that are yet to be solved, and that are even still emerging. In other words, this book looks to the future based on the most up-to-date knowledge.

The authors take an energetic, fresh approach to opening up new horizons, and their work here represents the leading edge of contemporary developmental studies of international repute. Readers—both students and established scientists in the biomedical field—will learn where we are, where the problems are, and which way to go in their understanding of the developmental processes. Stem cell sciences need a solid grounding in real developmental processes. The new principles presented in this book provide important suggestions for designing three-dimensional functional organs in vitro and in other forms, and thus will contribute significantly to the future of stem cell sciences and regenerative medicine.


cell competition embryogenesis heterologous tissue stem cells tissue regeneration

Editors and affiliations

  • Hisato Kondoh
    • 1
  • Atsushi Kuroiwa
    • 2
  1. 1.Graduate School of Frontier BiosciencesOsaka UniversityOsakaJapan
  2. 2.Graduate School ScienceNagoya UniversityNagoyaJapan

Bibliographic information