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  • © 2016

Etiology and Morphogenesis of Congenital Heart Disease

From Gene Function and Cellular Interaction to Morphology

  • Focuses on the etiology and morphogenesis of congenital heart disease
  • Includes contributions by an international group of distinguished scientists and clinicians
  • Highlights the latest research topics and techniques and includes chapters dedicated to clinical implications and future directions
  • Includes supplementary material: sn.pub/extras

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Softcover Book USD 59.99
Price excludes VAT (USA)
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  • Dispatched in 3 to 5 business days
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Hardcover Book USD 59.99
Price excludes VAT (USA)
  • Durable hardcover edition
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Table of contents (55 chapters)

  1. Valve Development and Diseases

    1. Front Matter

      Pages 131-133
    2. Molecular Mechanisms of Heart Valve Development and Disease

      • M. Victoria Gomez Stallons, Elaine E. Wirrig-Schwendeman, Ming Fang, Jonathan D. Cheek, Christina M. Alfieri, Robert B. Hinton et al.
      Pages 145-151Open Access
    3. The Role of the Epicardium in the Formation of the Cardiac Valves in the Mouse

      • Marie M. Lockhart, Maurice van den Hoff, Andy Wessels
      Pages 161-167Open Access
    4. TMEM100: A Novel Intracellular Transmembrane Protein Essential for Vascular Development and Cardiac Morphogenesis

      • Ken Mizuta, Masahide Sakabe, Satoshi Somekawa, Yoshihiko Saito, Osamu Nakagawa
      Pages 169-170Open Access
    5. The Role of Cell Autonomous Signaling by BMP in Endocardial Cushion Cells in AV Valvuloseptal Morphogenesis

      • Yukiko Sugi, Bin Zhou, Kei Inai, Yuji Mishina, Jessica L. Burnside
      Pages 171-173Open Access
  2. The Second Heart Field and Outflow Tract

    1. Front Matter

      Pages 175-176
    2. Properties of Cardiac Progenitor Cells in the Second Heart Field

      • Alexandre Francou, Robert G. Kelly
      Pages 177-182Open Access
    3. Nodal Signaling and Congenital Heart Defects

      • Ralston M. Barnes, Brian L. Black
      Pages 183-192Open Access
    4. Utilizing Zebrafish to Understand Second Heart Field Development

      • H. G. Knight, Deborah Yelon
      Pages 193-199Open Access
    5. A History and Interaction of Outflow Progenitor Cells Implicated in “Takao Syndrome”

      • Hiroyuki Yamagishi, Kazuki Kodo, Jun Maeda, Keiko Uchida, Takatoshi Tsuchihashi, Akimichi Shibata et al.
      Pages 201-209Open Access
    6. The Loss of Foxc2 Expression in the Outflow Tract Links the Interrupted Arch in the Conditional Foxc2 Knockout Mouse

      • Mohammad Khaja Mafij Uddin, Wataru Kimura, Mohammed Badrul Amin, Kasumi Nakamura, Mohammod Johirul Islam, Hiroyuki Yamagishi et al.
      Pages 211-213Open Access
    7. Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice

      • Takatoshi Tsuchihashi, Reina Ishizaki, Jun Maeda, Akimichi Shibata, Keiko Uchida, Deepak Srivastava et al.
      Pages 215-217Open Access
  3. Vascular Development and Diseases

    1. Front Matter

      Pages 219-220
    2. Extracellular Matrix Remodeling in Vascular Development and Disease

      • Kyoko Imanaka-Yoshida
      Pages 221-226Open Access
    3. The “Cardiac Neural Crest” Concept Revisited

      • Sachiko Miyagawa-Tomita, Yuichiro Arima, Hiroki Kurihara
      Pages 227-232Open Access
    4. Roles of Endothelial Hrt Genes for Vascular Development

      • Masahide Sakabe, Takashi Morioka, Hiroshi Kimura, Osamu Nakagawa
      Pages 233-235Open Access
    5. Inositol Trisphosphate Receptors in the Vascular Development

      • Keiko Uchida, Maki Nakazawa, Chihiro Yamagishi, Katsuhiko Mikoshiba, Hiroyuki Yamagishi
      Pages 237-239Open Access
    6. Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice

      • Yukako Yoshikane, Mitsuhisa Koga, Tamaki Cho, Kyoko Imanaka-Yoshida, Yumi Yamamoto, Junichi Hashimoto et al.
      Pages 241-242Open Access

About this book

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration.   This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.


Editors and Affiliations

  • Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan

    Toshio Nakanishi

  • Cardiovascular Developmental Biology Center, Medical University of South Carolina Clemson University, Charleston, USA

    Roger R. Markwald

  • Department of Pediatrics (Cardiology), Vanderbilt University, Nashville, USA

    H.Scott Baldwin

  • Pediatrics, Pharmacology and Toxicology, and Bioengineering, University of Louisville, Louisville, USA

    Bradley B. Keller

  • Gladstone Institute of Cardiovascular Disease, San Francisco, USA

    Deepak Srivastava

  • Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan

    Hiroyuki Yamagishi

Bibliographic Information

  • Book Title: Etiology and Morphogenesis of Congenital Heart Disease

  • Book Subtitle: From Gene Function and Cellular Interaction to Morphology

  • Editors: Toshio Nakanishi, Roger R. Markwald, H.Scott Baldwin, Bradley B. Keller, Deepak Srivastava, Hiroyuki Yamagishi

  • DOI: https://doi.org/10.1007/978-4-431-54628-3

  • Publisher: Springer Tokyo

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and the Author(s) 2016

  • Hardcover ISBN: 978-4-431-54627-6Published: 05 July 2016

  • Softcover ISBN: 978-4-431-56633-5Published: 07 June 2018

  • eBook ISBN: 978-4-431-54628-3Published: 24 June 2016

  • Edition Number: 1

  • Number of Pages: XII, 383

  • Number of Illustrations: 14 b/w illustrations, 95 illustrations in colour

  • Topics: Cardiology, Pediatric Surgery, Embryology, Pediatrics

Buy it now

Buying options

Softcover Book USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 59.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access