Table of contents

  1. Front Matter
    Pages i-xii
  2. From Molecular Mechanism to Intervention for Congenital Heart Diseases, Now and the Future

    1. Front Matter
      Pages 1-2
    2. Adriana C. Gittenberger-de Groot, E. M. Winter, M. J. Goumans, M. M. Bartelings, R. E. Poelmann
      Pages 11-18 Open Access
    3. Hidekazu Sekine, Tatsuya Shimizu, Teruo Okano
      Pages 19-24 Open Access
    4. Shugo Tohyama, Keiichi Fukuda
      Pages 25-31 Open Access
    5. Roger R. Markwald, Shibnath Ghatak, Suniti Misra, Ricardo A. Moreno-Rodríguez, Yukiko Sugi, Russell A. Norris
      Pages 33-45 Open Access
  3. Left-Right Axis and Heterotaxy Syndrome

    1. Front Matter
      Pages 47-48
    2. Isao Shiraishi
      Pages 49-56 Open Access
    3. Nikolai Klena, George Gabriel, Xiaoqin Liu, Hisato Yagi, You Li, Yu Chen et al.
      Pages 67-79 Open Access
    4. Akimichi Shibata, Keiko Uchida, Jun Maeda, Hiroyuki Yamagishi
      Pages 81-82 Open Access
  4. Cardiomyocyte and Myocardial Development

    1. Front Matter
      Pages 83-84
    2. Kenta Yashiro, Ken Suzuki
      Pages 85-91 Open Access
    3. Shalini A. Muralidhar, Hesham A. Sadek
      Pages 93-101 Open Access
    4. Guillermo Luxán, Gaetano D’Amato, José Luis de la Pompa
      Pages 103-114 Open Access
    5. Robert E. Poelmann, Bjarke Jensen, Margot M. Bartelings, Michael K. Richardson, Adriana C. Gittenberger-de Groot
      Pages 115-123 Open Access
    6. Hajime Fukui, Shigetomo Fukuhara, Naoki Mochizuki
      Pages 125-126 Open Access
    7. Yoshimi Hiraumi, Chengqun Huang, Allen M. Andres, Ying Xiong, Jennifer Ramil, Roberta A. Gottlieb
      Pages 127-128 Open Access
    8. Kazuhiro Maeda, Sachiko Miyagawa-Tomita, Toshio Nakanishi
      Pages 129-130 Open Access
  5. Valve Development and Diseases

    1. Front Matter
      Pages 131-133
    2. M. Victoria Gomez Stallons, Elaine E. Wirrig-Schwendeman, Ming Fang, Jonathan D. Cheek, Christina M. Alfieri, Robert B. Hinton et al.
      Pages 145-151 Open Access
    3. Marie M. Lockhart, Maurice van den Hoff, Andy Wessels
      Pages 161-167 Open Access
    4. Ken Mizuta, Masahide Sakabe, Satoshi Somekawa, Yoshihiko Saito, Osamu Nakagawa
      Pages 169-170 Open Access
    5. Yukiko Sugi, Bin Zhou, Kei Inai, Yuji Mishina, Jessica L. Burnside
      Pages 171-173 Open Access
  6. The Second Heart Field and Outflow Tract

    1. Front Matter
      Pages 175-176
    2. Alexandre Francou, Robert G. Kelly
      Pages 177-182 Open Access
    3. Ralston M. Barnes, Brian L. Black
      Pages 183-192 Open Access
    4. H. G. Knight, Deborah Yelon
      Pages 193-199 Open Access
    5. Hiroyuki Yamagishi, Kazuki Kodo, Jun Maeda, Keiko Uchida, Takatoshi Tsuchihashi, Akimichi Shibata et al.
      Pages 201-209 Open Access
    6. Mohammad Khaja Mafij Uddin, Wataru Kimura, Mohammed Badrul Amin, Kasumi Nakamura, Mohammod Johirul Islam, Hiroyuki Yamagishi et al.
      Pages 211-213 Open Access
    7. Takatoshi Tsuchihashi, Reina Ishizaki, Jun Maeda, Akimichi Shibata, Keiko Uchida, Deepak Srivastava et al.
      Pages 215-217 Open Access
  7. Vascular Development and Diseases

    1. Front Matter
      Pages 219-220
    2. Kyoko Imanaka-Yoshida
      Pages 221-226 Open Access
    3. Sachiko Miyagawa-Tomita, Yuichiro Arima, Hiroki Kurihara
      Pages 227-232 Open Access
    4. Masahide Sakabe, Takashi Morioka, Hiroshi Kimura, Osamu Nakagawa
      Pages 233-235 Open Access
    5. Keiko Uchida, Maki Nakazawa, Chihiro Yamagishi, Katsuhiko Mikoshiba, Hiroyuki Yamagishi
      Pages 237-239 Open Access
    6. Yukako Yoshikane, Mitsuhisa Koga, Tamaki Cho, Kyoko Imanaka-Yoshida, Yumi Yamamoto, Junichi Hashimoto et al.
      Pages 241-242 Open Access
  8. Ductus Arteriosus

    1. Front Matter
      Pages 243-244
    2. Adriana C. Gittenberger-de Groot, Regina Bokenkamp, Vered Raz, Conny van Munsteren, Robert E. Poelmann, Nimrat Grewal et al.
      Pages 245-251 Open Access
    3. Utako Yokoyama, Susumu Minamisawa, Yoshihiro Ishikawa
      Pages 253-258 Open Access
    4. Kazuo Momma, Mika Monma, Katsuaki Toyoshima, Emiko Hayama, Toshio Nakanishi
      Pages 263-265 Open Access
  9. Conduction System and Arrhythmia

    1. Front Matter
      Pages 267-268
    2. Jan Hendrik van Weerd, Vincent M. Christoffels
      Pages 269-280 Open Access
    3. Michael Bressan, Gary Liu, Jonathan D. Louie, Takashi Mikawa
      Pages 281-288 Open Access
    4. Rieko Asai, Yuichiro Arima, Daiki Seya, Ki-Sung Kim, Yumiko Kawamura, Yukiko Kurihara et al.
      Pages 289-290 Open Access
    5. Kumi Morikawa, Yasuaki Shirayoshi, Ichiro Hisatome
      Pages 291-292 Open Access

About this book


This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration.   This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.


Cellular Interaction Congenital Heart Disease iPS cells Gene functions Growth factors Transcription factors Cellular interactions Cardiac morphogenesis Cardiac morphology Vascular development

Editors and affiliations

  • Toshio Nakanishi
    • 1
  • Roger R. Markwald
    • 2
  • H.Scott Baldwin
    • 3
  • Bradley B. Keller
    • 4
  • Deepak Srivastava
    • 5
  • Hiroyuki Yamagishi
    • 6
  1. 1.Department of Pediatric CardiologyTokyo Women's Medical UniversityTokyoJapan
  2. 2.Cardiovascular Developmental Biology CenterMedical University of South Carolina Clemson UniversityCharlestonUSA
  3. 3.Department of Pediatrics (Cardiology)Vanderbilt UniversityNashvilleUSA
  4. 4.Pediatrics, Pharmacology and Toxicology, and BioengineeringUniversity of LouisvilleLouisvilleUSA
  5. 5.Gladstone Institute of Cardiovascular DiseaseSan FranciscoUSA
  6. 6.Pediatrics, Division of Pediatric CardiologyKeio University School of MedicineTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information The Editor(s) (if applicable) and the Author(s) 2016
  • License CC BY-NC
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54627-6
  • Online ISBN 978-4-431-54628-3
  • Buy this book on publisher's site