© 2015

Neurodegenerative Disorders as Systemic Diseases

  • Keiji Wada

Table of contents

  1. Front Matter
    Pages i-viii
  2. A New Concept of Neurodegeneration in Biology and Pathophysiology

    1. Front Matter
      Pages 1-1
    2. Tomohiko Ishihara, Masatoyo Nishizawa, Osamu Onodera
      Pages 3-22
    3. Masayuki Sekiguchi
      Pages 23-40
    4. Masaki Ueno, Toshihide Yamashita
      Pages 41-66
  3. Changes in Clinical Evaluation and New Biomarkers

    1. Front Matter
      Pages 67-67
    2. Chi-Jing Choong, Hisae Sumi-Akamaru, Hideki Mochizuki
      Pages 69-87
    3. Takashi Hanakawa
      Pages 89-114
  4. Risk Factors in Neurodegeneration

    1. Front Matter
      Pages 115-115
    2. Kazutaka Ohi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Satomi Umeda-Yano et al.
      Pages 135-155
  5. Future Directions for Therapy

  6. Health Promotion: Prevention and Quality of Life

About this book


This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.


Alzheimer’s disease Biomarkers Brain disorders Lou Gehrig’s disease (ALS) Neurodegeneration Paradigm shift Parkinson’s disease Quality of Life

Editors and affiliations

  • Keiji Wada
    • 1
  1. 1.National Center of Neurology and PsychiatryKodairaJapan

Bibliographic information