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Behçet's Disease

From Genetics to Therapies

  • Yoshiaki Ishigatsubo

Table of contents

  1. Front Matter
    Pages i-ix
  2. Yoshiaki Ishigatsubo, Mitsuhiro Takeno
    Pages 1-20
  3. Noboru Suzuki, Jun Shimizu
    Pages 21-39
  4. Akira Meguro, Nobuhisa Mizuki
    Pages 41-54
  5. Toshikatsu Kaburaki
    Pages 55-78
  6. Mitsuhiro Takeno, Haruko Ideguchi, Akiko Suda, Reikou Kamiyama, Yoshiaki Ishigatsubo
    Pages 79-100
  7. Shunsei Hirohata
    Pages 101-116
  8. Masakazu Nagahori
    Pages 117-127
  9. Fumio Kaneko, Ari Togashi, Erika Nomura, Koichiro Nakamura
    Pages 129-149
  10. Yoshiaki Ishigatsubo, Mitsuhiro Takeno
    Pages 151-172
  11. Back Matter
    Pages 173-176

About this book

Introduction

This book, besides reviewing basic and clinical aspects of Behçet's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease.
Although the cause of Behçet's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behçet's disease. Behçet's Disease:  From Genetics to Therapies  provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behçet's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.​

Keywords

Autoimmune Uveitis anti-TNF-alpha antibodies

Editors and affiliations

  • Yoshiaki Ishigatsubo
    • 1
  1. 1.Department of Internal Medicine and Clinical ImmunologyYokohama City University Graduate School of MedicineYokohamaJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-4-431-54487-6
  • Copyright Information Springer Japan 2015
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54486-9
  • Online ISBN 978-4-431-54487-6
  • Buy this book on publisher's site