Table of contents

  1. Front Matter
    Pages i-xii
  2. The History of Carbon-Ion Radiotherapy

    1. Front Matter
      Pages 1-1
    2. Hirohiko Tsujii
      Pages 3-10
  3. An Overview of Carbon-Ion Radiotherapy

  4. Radiobiology of Carbon-Ion Radiotherapy

    1. Front Matter
      Pages 23-23
    2. Yoshiya Furusawa
      Pages 25-37
    3. Naruhiro Matsufuji
      Pages 39-45
  5. Carbon-Ion Radiotherapy System

    1. Front Matter
      Pages 47-47
    2. Toshiyuki Shirai, Yuka Takei
      Pages 49-52
    3. Shigekazu Fukuda, Takuji Furukawa, Yoshiyuki Iwata
      Pages 53-64
    4. Manabu Mizota, Akifumi Fukumura
      Pages 65-70
    5. Shinichiro Mori
      Pages 71-78
    6. Takuji Furukawa, Shinichiro Mori
      Pages 79-84
  6. Treatment Planning of Carbon-Ion Radiotherapy

    1. Front Matter
      Pages 85-85
    2. Nobuyuki Kanematsu, Taku Inaniwa
      Pages 87-97
  7. Facility Design

    1. Front Matter
      Pages 99-99
  8. Oncology Information System

    1. Front Matter
      Pages 111-111
    2. Yutaka Ando
      Pages 113-117
  9. Evaluation of Treatment Outcome

  10. Head and Neck Tumors

    1. Front Matter
      Pages 125-125
    2. Azusa Hasegawa
      Pages 127-139
    3. Ryo Takagi
      Pages 141-147
    4. Masashi Koto
      Pages 149-152
  11. Skull Base and Paracervical Tumors

    1. Front Matter
      Pages 153-153
    2. Masashi Koto
      Pages 155-161
  12. Eye Tumors

    1. Front Matter
      Pages 163-163
    2. Hiroshi Tsuji, Shingo Toyama, Takuma Nomiya
      Pages 165-169
    3. Hiroshi Tsuji, Nobutaka Mizoguchi, Takuma Nomiya
      Pages 171-174
  13. Lung Tumors

    1. Front Matter
      Pages 175-175
    2. Naoyoshi Yamamoto, Mio Nakajima
      Pages 177-189
    3. Naoyoshi Yamamoto, Mio Nakajima
      Pages 191-194
  14. GI Tract Tumors

    1. Front Matter
      Pages 195-195
    2. Shigeo Yasuda
      Pages 197-201
    3. Shigeu Yamada, Satoshi Endo, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi et al.
      Pages 203-209
  15. Liver Tumors

    1. Front Matter
      Pages 211-211
    2. Shigeo Yasuda
      Pages 213-218
  16. Pancreatic Cancer

    1. Front Matter
      Pages 219-219
    2. Shigeu Yamada, Kohtaro Terashima, Makoto Shinoto, Shigeo Yasuda, Miho Shiomi, Tetsuro Isozaki
      Pages 221-228
  17. Genitourinary Tumors

    1. Front Matter
      Pages 229-229
    2. Hiroshi Tsuji, Hitoshi Ishikawa, Takuma Nomiya
      Pages 231-239
    3. Takuma Nomiya, Hiroshi Tsuji
      Pages 241-249
  18. Gynecologic Tumors

    1. Front Matter
      Pages 251-251
    2. Masaru Wakatsuki
      Pages 253-261
    3. Kumiko Karasawa
      Pages 263-267
  19. Bone and Soft Tissue Sarcomas

    1. Front Matter
      Pages 269-269
    2. Reiko Imai
      Pages 271-285

About this book


This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning.

Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning.

With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.


Cancer radiotherapy HIMAC Heavy ion Ion beams Protons Relative biological effectiveness

Editors and affiliations

  • Hirohiko Tsujii
    • 1
  • Tadashi Kamada
    • 2
  • Toshiyuki Shirai
    • 3
  • Koji Noda
    • 4
  • Hiroshi Tsuji
    • 5
  • Kumiko Karasawa
    • 6
  1. 1.National Inst. of Radiological SciencesChibaJapan
  2. 2.NIRSChibaJapan
  3. 3.NIRSChibaJapan
  4. 4.NIRSChibaJapan
  5. 5.NIRSChibaJapan
  6. 6.NIRSChibaJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Japan 2014
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54456-2
  • Online ISBN 978-4-431-54457-9
  • Buy this book on publisher's site