Cytokine Frontiers

Regulation of Immune Responses in Health and Disease

  • Takayuki Yoshimoto
  • Tomohiro Yoshimoto

Table of contents

  1. Front Matter
    Pages i-xii
  2. Cytokines in Inflammatory Disorders

    1. Front Matter
      Pages 1-1
    2. Charles A. Dinarello, Mihai G. Netea
      Pages 3-51
    3. Daisuke Kamimura, Yasunobu Arima, Toshio Hirano, Hideki Ogura, Masaaki Murakami
      Pages 53-78
    4. Harumichi Ishigame, Susumu Nakae
      Pages 79-101
    5. Wen Li, Yoshimasa Tanaka, Haruki Okamura
      Pages 103-123
    6. Jonathan P. Sherlock, Luis A. Zuniga, Daniel J. Cua
      Pages 179-198
    7. John E. Sims, Solenne Vigne, Cem Gabay, Jennifer E. Towne
      Pages 199-214
    8. Jagdeep Nanchahal, Peter Taylor, Richard Williams, Marc Feldmann
      Pages 215-244
  3. Cytokines in Allergic Disorders

    1. Front Matter
      Pages 245-245
    2. Hiroshi Nakajima, Tomohiro Tamachi, Koichi Hirose
      Pages 247-266
    3. Kazufumi Matsushita, Tomohiro Yoshimoto
      Pages 267-299
    4. Steven F. Ziegler, Florence Roan, Bryan D. Bell, Thomas A. Stoklasek, Masayuki Kitajima, Hongwei Han
      Pages 301-323
  4. Cytokines in Immunological Tolerance and Anti-inflammation

    1. Front Matter
      Pages 325-325
    2. Ashleigh Howes, Philippa Stimpson, Paul Redford, Leona Gabrysova, Anne O’Garra
      Pages 327-352
    3. Izuru Mizoguchi, Kaname Higuchi, Kana Mitobe, Ren Tsunoda, Junichiro Mizuguchi, Takayuki Yoshimoto
      Pages 353-375
    4. Greg M. Delgoffe, Dario A. A. Vignali
      Pages 377-387
  5. Back Matter
    Pages 389-396

About this book


This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.


Anti-inflammatory cytokines Pro-inflammatory cytokines Th2-type cytokines

Editors and affiliations

  • Takayuki Yoshimoto
    • 1
  • Tomohiro Yoshimoto
    • 2
  1. 1.Department of Immunoregulation Institute of Medical ScienceTokyo Medical UniversityTokyoJapan
  2. 2.Institute for Advanced Medical SciencesHyogo College of MedicineNishinomiyaJapan

Bibliographic information