A Diversity of Emerging Physiological and Pathological Activities

  • Atsushi Kumanogoh

Table of contents

  1. Front Matter
    Pages i-viii
  2. Manabu Negishi, Izumi Oinuma
    Pages 1-17
  3. Fumiyasu Imai, Yutaka Yoshida
    Pages 39-63
  4. E. Yvonne Jones
    Pages 87-106
  5. Gera Neufeld, Adi D. Sabag, Yelena Mumblat, Tatyana Smolkin, Ofra Kessler
    Pages 107-135
  6. Satoshi Nojima, Atsushi Kumanogoh
    Pages 137-157
  7. Mikihito Hayashi, Tomoki Nakashima, Hiroshi Takayanagi
    Pages 159-173
  8. Masaki Ieda, Keiichi Fukuda
    Pages 175-187
  9. Tatsusada Okuno, Yuji Nakatsuji
    Pages 189-205
  10. Toshihiko Toyofuku
    Pages 207-221
  11. Back Matter
    Pages 223-226

About this book


This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. Additionally, they have been implicated in the pathogenesis of various human diseases, including tumorigenesis/tumor metastasis, neuroregenerative diseases, retinal degeneration, irregular pulse/sudden death, and immune disorders. Based on this current research background, the book covers the essential state-of-the-art findings for basic scientists in biochemistry, molecular biology, neuroscience, developmental biology, and structural biology, as well as for physicians in neurology, cardiology, oncology, orthopedic surgery, otorhinolaryngology, ophthalmology, allergology, and rheumatology.


Axon guidance Bone homeostasis Cancer Immunity Neurodegenerative diseases Structural biology

Editors and affiliations

  • Atsushi Kumanogoh
    • 1
  1. 1.Department of Respiratory Medicine Allergy and Rheumatic DiseasesGraduate School of Medicine Osaka UniversitySuitaJapan

Bibliographic information