Matrix Metalloproteinases in Tissue Remodelling and Inflammation

  • Vincent Lagente
  • Elisabeth Boichot

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Sissie Wong, Mark A. Birrell, Maria G. Belvisi
    Pages 1-20
  3. Annie Pardo, Moisés Selman
    Pages 39-55
  4. Catherine le Quément, Vincent Lagente, Isabelle Guénon, Valeria Muzio, Jean-Yves Gillon, Elisabeth Boichot
    Pages 57-69
  5. Stéphane Jouneau, Guillaume Léveiller, Sylvie Caulet-Maugendre, Graziella Brinchault, Chantal Belleguic, Benoît Desrues et al.
    Pages 71-80
  6. Back Matter
    Pages 165-170

About this book

Introduction

Matrix metalloproteinases (MMPs) are proteolytic enzymes believed to be involved in many physiological and pathological processes associated with inflammatory reactions. MMP synthesis and functions are regulated by three major mechanisms including transcriptional activation, post-transcriptional processing, and control of activity by tissue inhibitors of metalloproteinases (TIMPs). Many cell types have been identified as producers of MMPs and TIMPs in a context of inflammatory processes. MMPs are involved in numerous inflammatory diseases, including respiratory, cardiovascular and central nervous system pathologies.

This volume presents new advances in the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs provides new insights in the relationship between activation of inflammatory cells and tissue remodelling and advises new therapeutic possibilities for the treatment of inflammatory diseases.

Keywords

Activation Atmen Tissue Remodelling asthma cell development diseases enzyme enzymes inflammation pathology protein research tissue transcription

Editors and affiliations

  • Vincent Lagente
    • 1
  • Elisabeth Boichot
    • 1
  1. 1.INSERM U620 Faculté des Sciences Pharmaceutiques et BiologiqueUniversité de Rennes 1Rennes CXFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7643-8585-9
  • Copyright Information Birkhäuser Basel 2008
  • Publisher Name Birkhäuser Basel
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-7643-8584-2
  • Online ISBN 978-3-7643-8585-9
  • About this book