Occupational Asthma

  • Torben Sigsgaard
  • Dick Heederik

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Hayley L. Jeal, Meinir G. Jones, Paul Cullinan
    Pages 33-55
  3. Kjell Torén, Paul D. Blanc
    Pages 57-70
  4. Paul K. Henneberger, Carrie A. Redlich
    Pages 89-100
  5. Dennis Nowak
    Pages 101-110
  6. Vanessa De Vooght, Valérie Hox, Benoit Nemery, Jeroen A. J. Vanoirbeek
    Pages 141-162
  7. Torben Sigsgaard, Øyvind Omland, Peter S. Thorne
    Pages 163-183
  8. Francine Kauffmann, Francesc Castro-Giner, Lidwien A. M. Smit, Rachel Nadif, Manolis Kogevinas
    Pages 205-228
  9. Olivier Vandenplas, Vinciane D’Alpaos
    Pages 271-279
  10. Vivi Schlünssen, Evert Meijer, Paul K. Henneberger
    Pages 281-298
  11. Kathleen Kreiss, Dick Heederik
    Pages 327-353
  12. Back Matter
    Pages 355-358

About this book


Recent developments in the field of occupational asthma research and clinical practice are the topic of this volume. The contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults is clearly described in an overview of the most recent epidemiological data from both general population and industry based studies. Emphasis is put on powerful approaches like the use of apprentices studies, which include young individuals, naïve with regard to occupational exposures. Diagnostic criteria for work related and work aggravated asthma are introduced and the latest insights in underlying mechanisms are covered as well. Specific emphasis is given to exposure response relationships for allergen exposure, which opens opportunities for primary and secondary prevention. Large gene-environment studies are undertaken for asthma and their contribution to understanding occupational asthma is discussed. Specific attention is given to whole genome screening approaches which involve with present technological possibilities the analysis of thousands of single nucleotide polymorphisms, versus the more focused candidate gene approach where genes with potential mechanistic plausibility are considered. Although the latter approach has been used more extensively, whole genome screening studies are becoming available soon, also for studies on occupational asthma. Management, prevention and surveillance are covered as well. All three areas are undergoing some changes in perception because of the exposure response relationships unraveled during the last decade. Diagnostic rules are introduced to rationalize the diagnostic workup and improve the cost benefit of surveillance schemes, and in preventive measures at large. This approach is only recently introduced in the field of occupational asthma and is expected to contribute even more in the coming years. Population studies, either general population studies, or work force based studies, have contributed enormously to our understanding of disease etiology and in the costs related to the disease. Issues in the design of such studies are discussed to assist the readers in designing and conducting their own study. Altogether this book gives a comprehensive insight in the present developments which will change the occupational asthma field the coming years.


Occupational disease Pulmonary disease Respiratory Infection allergy asthma diseases infection inflammation research

Editors and affiliations

  • Torben Sigsgaard
    • 1
  • Dick Heederik
    • 2
  1. 1.School of Public Health Dept. of Environmental and Occupational MedicineAarhus UniversityÅrhus CDenmark
  2. 2.Institute for Risk Assessment Sciences Division of Environmental and Occupational HealthUtrecht UniversityUtrechtNetherlands

Bibliographic information