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The Immune Synapse as a Novel Target for Therapy

  • Luis Graca

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Herman Waldmann, Elizabeth Adams, Stephen Cobbold
    Pages 49-56
  3. Damien Bresson, Matthias von Herrath
    Pages 57-70
  4. Yuan Zhai, Jerzy W. Kupiec-Weglinski
    Pages 71-86
  5. Francesca Fallarino, Carmine Vacca, Claudia Volpi, Maria T. Pallotta, Stefania Gizzi, Ursula Grohmann et al.
    Pages 87-106
  6. Mark R. Nicolls, Rasa Tamosiuniene
    Pages 107-128
  7. Bin Li, Xiaomin Song, Arabinda Samanta, Kathryn Bembas, Amy Brown, Geng Zhang et al.
    Pages 147-154
  8. Back Matter
    Pages 187-192

About this book

Introduction

The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell–APC junction. It plays an essential role in the control and nature of the immune response.

In recent years several approaches have been developed to reprogram the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as those targeting the lymphocyte co-receptor, costimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, LFA-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy.

This volume discusses the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It is of interest to clinicians and researchers working in this area.

Keywords

Activation Antigen Monoclonal Antibodies T cell antibody autoimmunity biochemistry cell clinical trial drug immunity lead regulation research vaccine

Editors and affiliations

  • Luis Graca
    • 1
  1. 1.Unidade de Imunologia Celular Instituto de Medicina MolecularFaculdade de Medicina da Universidade de LisboaLisboaPortugal

Bibliographic information