Adhesion Molecules: Function and Inhibition

  • Klaus Ley

Part of the Progress in Inflammation Research book series (PIR)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Capture and rolling

    1. Front Matter
      Pages 1-1
    2. Rodger P. McEver
      Pages 3-25
    3. Douglas A. Steeber, Hariharan Subramanian, Jamison J. Grailer, Rochelle M. Conway, Traci J. Storey
      Pages 27-70
    4. Daniel C. Bullard
      Pages 71-95
  3. Firm adhesion

  4. Transendothelial migration

    1. Front Matter
      Pages 199-199
    2. William A. Muller
      Pages 201-220
    3. Mathieu-Benoit Voisin, Sussan Nourshargh
      Pages 221-235
    4. Marko Salmi, Sirpa Jalkanen
      Pages 237-251
    5. Eric A. Severson, Charles A. Parkos
      Pages 271-288
    6. Karyn Yonekawa, John M. Harlan
      Pages 289-303
  5. Back Matter
    Pages 305-312

About this book


Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided.

The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.


Antigen biology cancer cancer research diseases glycoprotein immunology infectious disease infectious diseases migration physiology proteins regulation research tissue

Editors and affiliations

  • Klaus Ley
    • 1
  1. 1.La Jolla Institute for Allergy & ImmunologyLa JollaUSA

Bibliographic information