The CNS Control of Glucose Metabolism

  • Ernst Heinrich Grote

Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 31)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Ernst Heinrich Grote
    Pages 1-2
  3. Ernst Heinrich Grote
    Pages 3-35
  4. Ernst Heinrich Grote
    Pages 36-44
  5. Ernst Heinrich Grote
    Pages 45-132
  6. Ernst Heinrich Grote
    Pages 133-141
  7. Ernst Heinrich Grote
    Pages 142-145
  8. Back Matter
    Pages 146-160

About this book


In the clinic at Giessen during the last few years there has been an extensive programme of research into the various aspects of lesions of the diencephalon and brain stem and the associated autonomic and metabolic disturbances. As a continuation of this research programme Ernst Grote has investigated the central neuronal and hormonal factors acting on the peripheral regulation of glucose metabolism and their diverse inter-relationships. This research was made possible not only by the availability of well-documented clinical and experi­ mental material with primary and secondary lesions of the hypo­ thalamus and brain stem, but also by the advances in clinical endo­ crinology and the development of radio-immuno-assays. By continuous systematic investigation of the basic values and their reaction to stress-tests, as well as to trauma and operation, he has elucidated the basic facts of the central and peripheral mechanisms which are concerned in the regulation of glucose, and also their disturbances. Of particular significance are his descriptions and interpretations of the characteristic hypothalamic syndromes, as combinations of hyperglycaemia, hyperinsulinaemia and hyperglucagonaemia; dif­ ferent syndromes are produced by lesions at various levels of the brain stem and in central brain death. From this starting point it was possible to develop a rational treatment of this hormonal dys­ regulation by means of somatostatin.


Hirnerkrankung Hormonale Regulation Kohlenhydratstoffwechsel Metabolism Zentralnervöse Regulation brain nervous system trauma

Authors and affiliations

  • Ernst Heinrich Grote
    • 1
  1. 1.University Clinics GiessenFederal Republic of Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Vienna 1981
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-211-81619-6
  • Online ISBN 978-3-7091-8609-1
  • Series Print ISSN 0065-1419
  • Buy this book on publisher's site