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Clinical Aspects of Microdialysis

  • Aminadav Mendelowitsch
  • Helen Langemann
  • Beat Alessandri
  • Hans Landolt
  • Otmar Gratzl

Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 67)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Basic Science and Methodology

  3. Clinical Investigations

    1. H. Landolt, H. Langemann, B. Alessandri
      Pages 31-36
    2. J. Clay Goodman, S. P. Gopinath, A. B. Valadka, R. K. Narayan, R. G. Grossman, R. K. Simpson Jr. et al.
      Pages 37-39
    3. Alois Zauner, R. Bullock, A. J. Kuta, J. Woodward, H. F. Young
      Pages 40-44
    4. O. G. Nilsson, H. Säveland, F. Boris-Möller, L. Brandt, T. Wieloch
      Pages 45-47
    5. A. Mendelowitsch, H. Langemann, B. Alessandri, A. Kanner, H. Landolt, O. Gratzl
      Pages 48-52
    6. Ashfaq Shuaib, R. Kanthan, G. Goplen, R. Griebel, H. El-Azzouni, H. Miyashita et al.
      Pages 53-58
    7. P. N. Patsalos, M. T. O’Connell, H. C. Doheny, J. W. A. S. Sander, S. D. Shorvon
      Pages 59-62
    8. Andrew A. Kanner, A. Mendelowitsch, H. Langemann, B. Alessandri, O. Gratzl
      Pages 63-65
    9. John C. Lehmann, T. R. Jones, P. K. Mishra, S. Hamelin, S. N. Nair
      Pages 66-69
    10. H. Langemann, J. Habicht, A. Mendelowitsch, A. Kanner, B. Alessandri, H. Landolt et al.
      Pages 70-74
  4. Back Matter
    Pages 75-75

About these proceedings

Introduction

Microdialysis is a minimally invasive method which enables continuous monitoring of parameters in the extracellular space of various tissues. It has been investigated in animal models for over a decade, and many publications have provided insight into its advantages and disadvantages. However, in spite of its enormous potential for revealing metabolic processes in normal and pathological tissue, microdialysis in humans is still in its infancy. Clinical neurointensive medicine nowadays demands much more than conventional monitoring methods. As already shown by jugular bulb measurements of oxygen and lactate, in the future clinicians will want to have access to continuous neurochemical information from the patient. This information could be used to prevent those enigmatic secondary lesions which play such a negative role in neurointensive medicine, or at least enable treatment of them at an early stage. The extensive information now available from the laboratory would help with the interpretation of clinical analogues. In the University Clinic of Neurosurgery in Basel we have been involved in the field of micro dialytic monitoring for several years and have recognised the problems, both technical and ethical, which are involved in taking the difficult step from animal experiments to clinical application. In 1994 we thought that research on clinical microdialysis had reached the stage which would enable scientists and clinicians to have many fruitful discussions.

Keywords

brain care clinical application diabetes dialysis epilepsy head head injury intensive care metabolism monitoring newborn patients stroke surgery

Editors and affiliations

  • Aminadav Mendelowitsch
    • 1
  • Helen Langemann
    • 2
  • Beat Alessandri
    • 2
  • Hans Landolt
    • 3
  • Otmar Gratzl
    • 1
  1. 1.University Neurosurgical Clinic, Kantonsspital BaselBaselSwitzerland
  2. 2.Department of ResearchKantonsspital BaselBaselSwitzerland
  3. 3.Neurosurgical ClinicKantonsspital AarauAarauSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-6894-3
  • Copyright Information Springer-Verlag Vienna 1996
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-7091-7426-5
  • Online ISBN 978-3-7091-6894-3
  • Series Print ISSN 0065-1419
  • Buy this book on publisher's site