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Prion Diseases

Diagnosis and Pathogenesis

  • Martin H. Groschup
  • Hans A. Kretzschmar

Part of the Archives of Virology. Supplementa book series (ARCHIVES SUPPL, volume 16)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Pathogenesis of Prion Diseases

    1. Front Matter
      Pages 1-1
    2. M. Glatzel, M. A. Klein, S. Brandner, A. Aguzzi
      Pages 3-12
    3. K. L. Brown, K. Stewart, D. Ritchie, H. Fraser, W. I. Morrison, M. E. Bruce
      Pages 13-21
    4. M. Jeffrey, G. McGovern, S. Martin, C. M. Goodsir, K. L. Brown
      Pages 23-38
    5. V. Beringue, F. Lamoury, K. T. Adjou, T. Maignien, M. Demoy, P. Couvreur et al.
      Pages 39-56
    6. L. J. M. van Keulen, B. E. C. Schreuder, M. E. W. Vromans, J. P. M. Langeveld, M. A. Smits
      Pages 57-71
  3. Animal Models for Prion Diseases

    1. Front Matter
      Pages 73-73
    2. A. Buschmann, E. Pfaff, K. Reifenberg, H. M. Müller, M. H. Groschup
      Pages 75-86
    3. J. C. Manson, R. Barron, E. Jamieson, H. Baybutt, N. Tuzi, I. McConnell et al.
      Pages 95-102
    4. D. A. Harris, R. Chiesa, B. Drisaldi, E. Quaglio, A. Migheli, P. Piccardo et al.
      Pages 103-112
    5. M. R. Scott, S. Supattapone, H.-O. B. Nguyen, S. J. DeArmond, S. B. Prusiner
      Pages 113-124
  4. Epidemiology and Diagnosis of Prion Diseases

    1. Front Matter
      Pages 125-125
    2. D. Heim, J. W. Wilesmith
      Pages 127-133
    3. J. W. Ironside
      Pages 143-151
    4. S. Poser, I. Zerr, A. Schroeter, M. Otto, A. Giese, B. J. Steinhoff et al.
      Pages 153-159
    5. W. J. Schulz-Schaeffer, R. Fatzer, M. Vandevelde, H. A. Kretzschmar
      Pages 173-180
    6. N. Hunter, W. Goldmann, E. Marshall, G. O’Neill
      Pages 181-188
    7. B. Oesch, M. Doherr, D. Heim, K. Fischer, S. Egli, S. Bolliger et al.
      Pages 189-195
  5. Characterization of the Infectious Agent

    1. Front Matter
      Pages 207-207
    2. S. G. Chen, W. Zou, P. Parchi, P. Gambetti
      Pages 209-216
    3. M. H. Groschup, T. Kuczius, F. Junghans, T. Sweeney, W. Bodemer, A. Buschmann
      Pages 217-226
  6. Structure and Function of PrP

    1. Front Matter
      Pages 237-237
    2. H. A. Kretzschmar, T. Tings, A. Madlung, A. Giese, J. Herms
      Pages 239-249
    3. K. Post, D. R. Brown, M. Groschup, H. A. Kretzschmar, D. Riesner
      Pages 265-273
  7. PrP Conversion

About this book

Introduction

A comprehensive understanding of the biology of prion diseases is crucial for risk assessment as regards both humans and animals. To further the communication of the current knowledge and the exchange of diagnostic technologies in the scientific community, a symposium on the 'Characterization and Diagnosis of Prion Diseases' was held from September 23-25, 1999 in Tübingen, Germany. The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this Supplementum to Archives of Virology twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains. This selection attempts to reflect the current state of the art, but cannot possibly represent the whole spectrum of research in the prion field.

Keywords

BSE Creutzfeld-Jakob Krankheit Creutzfeldt-Jakob disease PET Prionen antibody bovine spongiform encephalopathy bovine spongioforme Enzephalopathie dendritic cells differential diagnosis pathogenesis positron emission tomography (PET) prions tissue virology

Editors and affiliations

  • Martin H. Groschup
    • 1
  • Hans A. Kretzschmar
    • 2
  1. 1.Institut für ImmunologieBundesforschungsanstalt für Viruskrankheiten der TiereTübingenGermany
  2. 2.Institut für NeuropathologieLudwig-Maximilians-UniversitätMünchenGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-6308-5
  • Copyright Information Springer-Verlag/Wien 2000
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-211-83529-6
  • Online ISBN 978-3-7091-6308-5
  • Series Print ISSN 0939-1983
  • Buy this book on publisher's site