The Intervertebral Disc

Molecular and Structural Studies of the Disc in Health and Disease

  • Irving M. Shapiro
  • Makarand V. Risbud

Table of contents

  1. Front Matter
    Pages i-x
  2. Biomechanical and Molecular Studies of the Intervertebral Disc

    1. Front Matter
      Pages 1-1
    2. Daniel H. Cortes, Dawn M. Elliott
      Pages 17-31
    3. Megan K. Cox, Rosa Serra
      Pages 33-51
    4. James Melrose, Peter Roughley
      Pages 53-77
    5. Jason C. Ho, James Wylie, Suneel S. Apte
      Pages 125-135
  3. Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities

    1. Front Matter
      Pages 137-137
    2. Yue Wang, Michele C. Battié
      Pages 139-156
    3. Anita Yee, Danny Chan
      Pages 157-176
    4. Stephen M. Richardson, Anthony J. Freemont, Judith A. Hoyland
      Pages 177-200
    5. Ari Borthakur, Ravinder Reddy
      Pages 201-212
    6. Ravi R. Patel, Jeffrey A. Rihn, Ravi K. Ponnoppan, Todd J. Albert
      Pages 213-224
    7. Daniel G. Kang, Melvin D. Helgeson, Alexander R. Vaccaro
      Pages 225-246
    8. Isaac L. Moss, Howard S. An, Francis H. Shen, Zemin Li, Gunnar B. J. Andersson, Yejia Zhang
      Pages 247-259
    9. John A. Abraham, Brian Neuman, Francis J. Hornicek
      Pages 277-288
  4. Models of Disc Disease and Biological Regeneration

    1. Front Matter
      Pages 289-289
    2. Shyam A. Patel, Christopher K. Kepler, Thomas P. Schaer, D. Greg Anderson
      Pages 291-303
    3. Beth A. Winkelstein, Kyle D. Allen, Lori A. Setton
      Pages 305-326
    4. Laura Mangiavini, Rita Gerard-O’Riley, Ernestina Schipani
      Pages 341-351
    5. Svenja Illien-Jünger, Benjamin A. Walter, Jillian E. Mayer, Andrew C. Hecht, James C. Iatridis
      Pages 353-371
    6. Daisuke Sakai, Joji Mochida
      Pages 373-383
    7. Zulma Gazit, Nadav Kimelman-Bleich, Olga Mizrahi, Dan Gazit
      Pages 385-400
    8. Won C. Bae, Koichi Masuda
      Pages 401-416
    9. Rita Kandel, Paul Santerre, Eric Massicotte, Mark Hurtig
      Pages 417-433
  5. Back Matter
    Pages 435-446

About this book


The intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain.

Written by leading scientists and clinicians, this is the only book in the past fifty years devoted entirely to the study of the intervertebral disc. The first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies for mitigating the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is dedicated to approaches that model normal development, and the elucidation of the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques. 

This unique and authoritative book bridges the gap between the basic and clinical sciences; its target audience includes basic scientists, orthopedists, neurologists, rehabilitation and physical therapists, primary care physicians and chiropractors, while it also addresses the needs of graduate students, medical students, interns, fellows, and patients who suffer from disc-related pathologies.


back pain degenerative disc disease disc degeneration intervertebral disc

Editors and affiliations

  • Irving M. Shapiro
    • 1
  • Makarand V. Risbud
    • 2
  1. 1.Jefferson Medical College Div Ortho Rsch/Dept Othro SurgeryThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Jefferson Medical College Department of Orthopaedic SurgeryThomas Jefferson UniversityPhiladelphiaUSA

Bibliographic information